FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002000851> ?p ?o ?g. }

• W2002000851 endingPage "103" @default.
• W2002000851 startingPage "94" @default.
• W2002000851 abstract "Metal oxide nanoparticles are widely used in the paint and coating industry as well as in cosmetics, but the knowledge of their possible interactions with the immune system is very limited. Our aims were to investigate if commercially available TiO2 and ZnO nanoparticles may affect different human immune cells and their production of exosomes, nano-sized vesicles that have a role in cell to cell communication. We found that the TiO2 or ZnO nanoparticles at concentrations from 1 to 100 μg/mL did not affect the viability of primary human peripheral blood mononuclear cells (PBMC). In contrast, monocyte-derived dendritic cells (MDDC) reacted with a dose dependent increase in cell death and caspase activity to ZnO but not to TiO2 nanoparticles. Non-toxic exposure, 10 μg/mL, to TiO2 and ZnO nanoparticles did not significantly alter the phenotype of MDDC. Interestingly, ZnO but not TiO2 nanoparticles induced a down regulation of FcγRIII (CD16) expression on NK-cells in the PBMC population, suggesting that subtoxic concentrations of ZnO nanoparticles might have an effect on FcγR-mediated immune responses. The phenotype and size of exosomes produced by PBMC or MDDC exposed to the nanoparticles were similar to that of exosomes harvested from control cultures. TiO2 or ZnO nanoparticles could not be detected within or associated to exosomes as analyzed with TEM. We conclude that TiO2 and ZnO nanoparticles differently affect immune cells and that evaluations of nanoparticles should be performed even at subtoxic concentrations on different primary human immune cells when investigating potential effects on immune functions." @default.
• W2002000851 created "2016-06-24" @default.
• W2002000851 creator A5014381301 @default.
• W2002000851 creator A5032094377 @default.
• W2002000851 creator A5057129841 @default.
• W2002000851 creator A5062660549 @default.
• W2002000851 creator A5071600466 @default.
• W2002000851 creator A5071905026 @default.
• W2002000851 creator A5084369549 @default.
• W2002000851 date "2012-10-01" @default.
• W2002000851 modified "2023-10-14" @default.
• W2002000851 title "Effects of subtoxic concentrations of TiO2 and ZnO nanoparticles on human lymphocytes, dendritic cells and exosome production" @default.
• W2002000851 cites W1538522759 @default.
• W2002000851 cites W1615139577 @default.
• W2002000851 cites W1749515626 @default.
• W2002000851 cites W1968012969 @default.
• W2002000851 cites W1976161883 @default.
• W2002000851 cites W1979519066 @default.
• W2002000851 cites W1979751563 @default.
• W2002000851 cites W1980109201 @default.
• W2002000851 cites W1985069370 @default.
• W2002000851 cites W1986321004 @default.
• W2002000851 cites W1987019376 @default.
• W2002000851 cites W1987710873 @default.
• W2002000851 cites W1990075727 @default.
• W2002000851 cites W1996976348 @default.
• W2002000851 cites W2000202312 @default.
• W2002000851 cites W2006420605 @default.
• W2002000851 cites W2015050803 @default.
• W2002000851 cites W2017678578 @default.
• W2002000851 cites W2020992406 @default.
• W2002000851 cites W2022235108 @default.
• W2002000851 cites W2029047024 @default.
• W2002000851 cites W2034843771 @default.
• W2002000851 cites W2043934279 @default.
• W2002000851 cites W2044638539 @default.
• W2002000851 cites W2046660653 @default.
• W2002000851 cites W2054348933 @default.
• W2002000851 cites W2059197379 @default.
• W2002000851 cites W2076759023 @default.
• W2002000851 cites W2080885599 @default.
• W2002000851 cites W2085938864 @default.
• W2002000851 cites W2088163595 @default.
• W2002000851 cites W2091627929 @default.
• W2002000851 cites W2098949645 @default.
• W2002000851 cites W2111560326 @default.
• W2002000851 cites W2114146420 @default.
• W2002000851 cites W2116359172 @default.
• W2002000851 cites W2122635106 @default.
• W2002000851 cites W2127911529 @default.
• W2002000851 cites W2129062330 @default.
• W2002000851 cites W2130282765 @default.
• W2002000851 cites W2140740716 @default.
• W2002000851 cites W2141436376 @default.
• W2002000851 cites W2147116051 @default.
• W2002000851 cites W2155366992 @default.
• W2002000851 cites W2163438544 @default.
• W2002000851 cites W2168611799 @default.
• W2002000851 cites W2169764152 @default.
• W2002000851 cites W3142110808 @default.
• W2002000851 cites W4254283855 @default.
• W2002000851 doi "https://doi.org/10.1016/j.taap.2012.07.021" @default.
• W2002000851 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22842014" @default.
• W2002000851 hasPublicationYear "2012" @default.
• W2002000851 type Work @default.
• W2002000851 sameAs 2002000851 @default.
• W2002000851 citedByCount "75" @default.
• W2002000851 countsByYear W20020008512013 @default.
• W2002000851 countsByYear W20020008512014 @default.
• W2002000851 countsByYear W20020008512015 @default.
• W2002000851 countsByYear W20020008512016 @default.
• W2002000851 countsByYear W20020008512017 @default.
• W2002000851 countsByYear W20020008512018 @default.
• W2002000851 countsByYear W20020008512019 @default.
• W2002000851 countsByYear W20020008512020 @default.
• W2002000851 countsByYear W20020008512021 @default.
• W2002000851 countsByYear W20020008512022 @default.
• W2002000851 countsByYear W20020008512023 @default.
• W2002000851 crossrefType "journal-article" @default.
• W2002000851 hasAuthorship W2002000851A5014381301 @default.
• W2002000851 hasAuthorship W2002000851A5032094377 @default.
• W2002000851 hasAuthorship W2002000851A5057129841 @default.
• W2002000851 hasAuthorship W2002000851A5062660549 @default.
• W2002000851 hasAuthorship W2002000851A5071600466 @default.
• W2002000851 hasAuthorship W2002000851A5071905026 @default.
• W2002000851 hasAuthorship W2002000851A5084369549 @default.
• W2002000851 hasConcept C104317684 @default.
• W2002000851 hasConcept C137061746 @default.
• W2002000851 hasConcept C145059251 @default.
• W2002000851 hasConcept C1491633281 @default.
• W2002000851 hasConcept C155672457 @default.
• W2002000851 hasConcept C171250308 @default.
• W2002000851 hasConcept C185592680 @default.
• W2002000851 hasConcept C192562407 @default.
• W2002000851 hasConcept C202751555 @default.
• W2002000851 hasConcept C203014093 @default.
• W2002000851 hasConcept C20518536 @default.
• W2002000851 hasConcept C2778170410 @default.

• next