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- W2002000897 abstract "Detection of apoptotic cells and of immunoreactivity to transforming growth factor alpha (TGF-α) and to its ligand, epidermal growth factor receptor (EGFR), was studied in 20 cases of parathyroid adenoma. The DNA nick-end labelling method revealed that 85% of these adenomas contained apoptotic cells. Detection rates of TGF-α and EGFR were very high, but neither TGF-α nor EGFR was correlated to apoptosis. As TGF-α exerts its effect via EGFR, the concomitant demonstration of the two factors occurring in both the adenomatous tissue and the surrounding rim of normal tissue may reflect a significant mutual association. The markers were located mainly within the cytoplasm, indicating their important role in growth regulation, cell differentiation and cell function. The synchronous expression of TGF-α and EGFR in both parathyroid adenomas and normal glandular parenchyma suggests that these functions may be mediated by an autocrine mechanism." @default.
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- W2002000897 date "1997-11-01" @default.
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- W2002000897 title "Apoptosis and Growth Factors in Parathyroid Adenomas" @default.
- W2002000897 doi "https://doi.org/10.1055/s-2007-979098" @default.
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