FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002009168> ?p ?o ?g. }

• W2002009168 endingPage "156" @default.
• W2002009168 startingPage "146" @default.
• W2002009168 abstract "BACKGROUND: The natural history of surgically treated intracranial meningiomas can be quite variable. Recurrence and patient outcome cannot currently be predicted with accuracy. OBJECTIVE: To explore the potential roles of tumor hypoxia-regulated biological markers, preoperative imaging, measures of proliferation, and angiogenesis in predicting patient outcome. METHODS: Tissue from 263 patients (average follow-up, 75 months) was examined for molecular markers hypoxia-inducible factor-1α (HIF-1α), carbonic anhydrase-IX (CA-IX), and glucose transporter-1 (Glut-1); vascular endothelial growth factor (VEGF); proliferation (MIB-1); and microvascular density (MVD) (Factor VIII). Preoperative magnetic resonance images were also examined for tumor size and peritumoral brain edema (PTBE). RESULTS: VEGF, HIF-1α, CA-IX, and Glut-1 are positively correlated (P < .001–.005). PTBE was associated with higher grade (P = .03), larger tumors (P = .02), and log of MVD (P = .004). Progression-free survival (PFS) was associated with higher grade (P < .001), subtotal resection (P = .004), VEGF expression (P = .004), and log of MIB-labeling index (P < .001) on pairwise comparisons. Using multivariate analysis, PFS was associated with subtotal resection (HR 2.71, P = .027), higher grade (HR 6.29, P < .001), higher VEGF expression (HR 1.52, P = .038), and log of MIB-labeling index (HR 1.68, P = .005). Shorter overall survival was associated with subtotal resection (HR 3.23, P = .002), higher grade (HR 4.47, P < .001), higher expression of HIF-1α (HR 1.56, P < .001) and Glut-1 (HR 1.39, P = .02), and log of MIB-labeling index (HR 1.87, P < .001) when controlled for age. CONCLUSION: HIF, VEGF, and MIB-1 are significantly correlated with tumor recurrence. With further study, these molecular markers may be used to predict outcome for patients with intracranial meningiomas. ABBREVIATIONS: CA-IX, carbonic anhydrase-IX Glut-1, glucose transporter-1 HIF-1α, hypoxia-inducible factor-1α MVD, microvascular density OS, overall survival PFS, progression-free survival PI, proliferation index PTBE, peritumoral brain edema VEGF, vascular endothelial growth factor WHO, World Health Organization" @default.
• W2002009168 created "2016-06-24" @default.
• W2002009168 creator A5079729144 @default.
• W2002009168 creator A5080895084 @default.
• W2002009168 date "2012-07-01" @default.
• W2002009168 modified "2023-10-03" @default.
• W2002009168 title "Predicting Outcomes of Patients With Intracranial Meningiomas Using Molecular Markers of Hypoxia, Vascularity, and Proliferation" @default.
• W2002009168 cites W1520587823 @default.
• W2002009168 cites W1527368436 @default.
• W2002009168 cites W1584308853 @default.
• W2002009168 cites W1600178338 @default.
• W2002009168 cites W1856093690 @default.
• W2002009168 cites W1965137624 @default.
• W2002009168 cites W1975692192 @default.
• W2002009168 cites W1982904703 @default.
• W2002009168 cites W1987904413 @default.
• W2002009168 cites W1989138467 @default.
• W2002009168 cites W2002006301 @default.
• W2002009168 cites W2010382757 @default.
• W2002009168 cites W2011151332 @default.
• W2002009168 cites W2013445913 @default.
• W2002009168 cites W2018635032 @default.
• W2002009168 cites W2026642573 @default.
• W2002009168 cites W2027838880 @default.
• W2002009168 cites W2031733465 @default.
• W2002009168 cites W2035069566 @default.
• W2002009168 cites W2035182290 @default.
• W2002009168 cites W2045693295 @default.
• W2002009168 cites W2047841717 @default.
• W2002009168 cites W2047999584 @default.
• W2002009168 cites W2049571882 @default.
• W2002009168 cites W2051215110 @default.
• W2002009168 cites W2054169323 @default.
• W2002009168 cites W2055145844 @default.
• W2002009168 cites W2062313040 @default.
• W2002009168 cites W2064720635 @default.
• W2002009168 cites W2067316523 @default.
• W2002009168 cites W2067898417 @default.
• W2002009168 cites W2072411420 @default.
• W2002009168 cites W2072585296 @default.
• W2002009168 cites W2078828166 @default.
• W2002009168 cites W2087816394 @default.
• W2002009168 cites W2092804661 @default.
• W2002009168 cites W2114552801 @default.
• W2002009168 cites W2117692326 @default.
• W2002009168 cites W2123151813 @default.
• W2002009168 cites W2130690650 @default.
• W2002009168 cites W2130826312 @default.
• W2002009168 cites W2141007603 @default.
• W2002009168 cites W2160382843 @default.
• W2002009168 cites W2161976618 @default.
• W2002009168 cites W2339836440 @default.
• W2002009168 cites W4211028957 @default.
• W2002009168 cites W4231282320 @default.
• W2002009168 doi "https://doi.org/10.1227/neu.0b013e3182567886" @default.
• W2002009168 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22472549" @default.
• W2002009168 hasPublicationYear "2012" @default.
• W2002009168 type Work @default.
• W2002009168 sameAs 2002009168 @default.
• W2002009168 citedByCount "50" @default.
• W2002009168 countsByYear W20020091682012 @default.
• W2002009168 countsByYear W20020091682013 @default.
• W2002009168 countsByYear W20020091682014 @default.
• W2002009168 countsByYear W20020091682015 @default.
• W2002009168 countsByYear W20020091682016 @default.
• W2002009168 countsByYear W20020091682017 @default.
• W2002009168 countsByYear W20020091682018 @default.
• W2002009168 countsByYear W20020091682019 @default.
• W2002009168 countsByYear W20020091682020 @default.
• W2002009168 countsByYear W20020091682021 @default.
• W2002009168 countsByYear W20020091682022 @default.
• W2002009168 countsByYear W20020091682023 @default.
• W2002009168 crossrefType "journal-article" @default.
• W2002009168 hasAuthorship W2002009168A5079729144 @default.
• W2002009168 hasAuthorship W2002009168A5080895084 @default.
• W2002009168 hasConcept C126322002 @default.
• W2002009168 hasConcept C126838900 @default.
• W2002009168 hasConcept C142724271 @default.
• W2002009168 hasConcept C143409427 @default.
• W2002009168 hasConcept C167734588 @default.
• W2002009168 hasConcept C178596483 @default.
• W2002009168 hasConcept C178790620 @default.
• W2002009168 hasConcept C185592680 @default.
• W2002009168 hasConcept C204232928 @default.
• W2002009168 hasConcept C2776085573 @default.
• W2002009168 hasConcept C2777025900 @default.
• W2002009168 hasConcept C2778271429 @default.
• W2002009168 hasConcept C2780394083 @default.
• W2002009168 hasConcept C2910938049 @default.
• W2002009168 hasConcept C38180746 @default.
• W2002009168 hasConcept C540031477 @default.
• W2002009168 hasConcept C71924100 @default.
• W2002009168 hasConcept C7836513 @default.
• W2002009168 hasConcept C90924648 @default.
• W2002009168 hasConceptScore W2002009168C126322002 @default.
• W2002009168 hasConceptScore W2002009168C126838900 @default.
• W2002009168 hasConceptScore W2002009168C142724271 @default.
• W2002009168 hasConceptScore W2002009168C143409427 @default.

• next