FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002014356> ?p ?o ?g. }

• W2002014356 endingPage "188" @default.
• W2002014356 startingPage "177" @default.
• W2002014356 abstract "1. It has been suggested that pituitary adenylate cyclase activating peptide (PACAP) may be involved in the non-adrenergic, non-cholinergic (NANC) inhibitory response of longitudinal muscle of rat distal colon. In this study, we have investigated the intracellular mechanism of PACAP-induced relaxation in this muscle. 2. PACAP induced an apamin-sensitive relaxation of the longitudinal muscle. The tyrosine kinase inhibitors genistein at 10 microM and tyrphostin 25 at 30 microM, but not the cyclic AMP-dependent protein kinase inhibitor Rp-8-bromoadenosine-3',5'-cyclic monophosphorothioate at 30 microM significantly inhibited the PACAP-induced relaxation to 60% and 25% of control values, respectively. PACAP did not increase the cyclic AMP content of the muscle. 3. Tyrphostin 25 at 10 microM significantly inhibited the relaxation of longitudinal muscle induced by electrical field stimulation (EFS), to 50% of control values. Apamin at 1 microM, an antagonist of small conductance Ca2+-activated K+ channels, also inhibited the relaxation, to 42 % of control values. The inhibitory effects of tyrphostin 25 and apamin were not additive (44 % of control values). 4. PACAP induced an apamin-sensitive, slow hyperpolarization of the cell membrane of the muscle. Tyrphostin 25 at 3 microM inhibited this PACAP-induced hyperpolarization. Tyrphostin 25 at 10 microM and genistein at 10 microM inhibited the apamin-sensitive inhibitory junction potentials induced by a single pulse of EFS. 5. The PACAP-induced relaxation of longitudinal muscle occurred with a concomitant decrease in intracellular Ca2+ levels ([Ca2+]i). Tyrphostin 25 at 10 microM and apamin at 1 microM abolished these PACAP-induced responses. 6. From these findings it is suggested that the activation of tyrosine kinase is involved in PACAP-induced relaxation of longitudinal muscle from rat distal colon, 'upstream of' the activation of apamin-sensitive K+ channels." @default.
• W2002014356 created "2016-06-24" @default.
• W2002014356 creator A5010040847 @default.
• W2002014356 creator A5046805440 @default.
• W2002014356 creator A5048362422 @default.
• W2002014356 creator A5072556940 @default.
• W2002014356 creator A5077667212 @default.
• W2002014356 creator A5081133146 @default.
• W2002014356 creator A5083073388 @default.
• W2002014356 creator A5085929178 @default.
• W2002014356 date "1999-01-01" @default.
• W2002014356 modified "2023-09-24" @default.
• W2002014356 title "Tyrosine kinase involvement in apamin‐sensitive inhibitory responses of rat distal colon" @default.
• W2002014356 cites W1596040936 @default.
• W2002014356 cites W1656644300 @default.
• W2002014356 cites W1820557413 @default.
• W2002014356 cites W1964285407 @default.
• W2002014356 cites W1965021019 @default.
• W2002014356 cites W1966112698 @default.
• W2002014356 cites W1974290405 @default.
• W2002014356 cites W1979024318 @default.
• W2002014356 cites W1981423842 @default.
• W2002014356 cites W1984434545 @default.
• W2002014356 cites W1999788892 @default.
• W2002014356 cites W2000400143 @default.
• W2002014356 cites W2002185725 @default.
• W2002014356 cites W2009087599 @default.
• W2002014356 cites W2013509592 @default.
• W2002014356 cites W2018683381 @default.
• W2002014356 cites W2029585845 @default.
• W2002014356 cites W2035459073 @default.
• W2002014356 cites W2039548501 @default.
• W2002014356 cites W2050780404 @default.
• W2002014356 cites W2054371611 @default.
• W2002014356 cites W2054818418 @default.
• W2002014356 cites W2058100090 @default.
• W2002014356 cites W2058108253 @default.
• W2002014356 cites W2058839845 @default.
• W2002014356 cites W2065183122 @default.
• W2002014356 cites W2073577985 @default.
• W2002014356 cites W2079097756 @default.
• W2002014356 cites W2080475705 @default.
• W2002014356 cites W2085644581 @default.
• W2002014356 cites W2102742081 @default.
• W2002014356 cites W2117582045 @default.
• W2002014356 cites W2168776095 @default.
• W2002014356 cites W2171121921 @default.
• W2002014356 cites W2222790656 @default.
• W2002014356 cites W2247023146 @default.
• W2002014356 cites W2284003820 @default.
• W2002014356 cites W2400963480 @default.
• W2002014356 cites W2412385351 @default.
• W2002014356 doi "https://doi.org/10.1111/j.1469-7793.1999.177af.x" @default.
• W2002014356 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2269060" @default.
• W2002014356 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9831725" @default.
• W2002014356 hasPublicationYear "1999" @default.
• W2002014356 type Work @default.
• W2002014356 sameAs 2002014356 @default.
• W2002014356 citedByCount "22" @default.
• W2002014356 countsByYear W20020143562014 @default.
• W2002014356 crossrefType "journal-article" @default.
• W2002014356 hasAuthorship W2002014356A5010040847 @default.
• W2002014356 hasAuthorship W2002014356A5046805440 @default.
• W2002014356 hasAuthorship W2002014356A5048362422 @default.
• W2002014356 hasAuthorship W2002014356A5072556940 @default.
• W2002014356 hasAuthorship W2002014356A5077667212 @default.
• W2002014356 hasAuthorship W2002014356A5081133146 @default.
• W2002014356 hasAuthorship W2002014356A5083073388 @default.
• W2002014356 hasAuthorship W2002014356A5085929178 @default.
• W2002014356 hasBestOaLocation W20020143562 @default.
• W2002014356 hasConcept C118303440 @default.
• W2002014356 hasConcept C126322002 @default.
• W2002014356 hasConcept C131453863 @default.
• W2002014356 hasConcept C134018914 @default.
• W2002014356 hasConcept C149786707 @default.
• W2002014356 hasConcept C170493617 @default.
• W2002014356 hasConcept C178790620 @default.
• W2002014356 hasConcept C185592680 @default.
• W2002014356 hasConcept C2776919887 @default.
• W2002014356 hasConcept C2779496938 @default.
• W2002014356 hasConcept C42362537 @default.
• W2002014356 hasConcept C50254741 @default.
• W2002014356 hasConcept C55493867 @default.
• W2002014356 hasConcept C62478195 @default.
• W2002014356 hasConcept C66974803 @default.
• W2002014356 hasConcept C71924100 @default.
• W2002014356 hasConcept C79879829 @default.
• W2002014356 hasConcept C8330315 @default.
• W2002014356 hasConcept C83743174 @default.
• W2002014356 hasConcept C86803240 @default.
• W2002014356 hasConceptScore W2002014356C118303440 @default.
• W2002014356 hasConceptScore W2002014356C126322002 @default.
• W2002014356 hasConceptScore W2002014356C131453863 @default.
• W2002014356 hasConceptScore W2002014356C134018914 @default.
• W2002014356 hasConceptScore W2002014356C149786707 @default.
• W2002014356 hasConceptScore W2002014356C170493617 @default.
• W2002014356 hasConceptScore W2002014356C178790620 @default.
• W2002014356 hasConceptScore W2002014356C185592680 @default.

• next