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• W2002014768 abstract "The role of protein kinase C (PKC) system on CD3 expression on adult T-cell leukaemia (ATL) was examined. The down-regulation of CD3 on ATL cells is reportedly induced by CD3 down-regulating factor (CD3DF) contained in serum and culture supernatants of leukaemia cells from acute type ATL patients. After we cultured normal PBMC with a PKC inhibitor, H-7, CD3DF activity for PBMC was reduced significantly. Culture with H-7 of HTLV-1 transformed T cells, ATL-2 cells whose CD3 expression had been decreased, led to enhancement of CD3 expression in a time-dependent manner. These findings suggest that CD3DF may play an important role as a PKC system activator, resulting in CD3 down-regulation." @default.
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• W2002014768 date "1994-02-01" @default.
• W2002014768 modified "2023-09-26" @default.
• W2002014768 title "Possible involvement of protein kinase C activation in down-regulation of CD3 antigen on adult T cell leukaemia cells" @default.
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• W2002014768 doi "https://doi.org/10.1111/j.1365-2141.1994.tb04751.x" @default.
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