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- W2002021305 abstract "Ionic channels in nerve and muscle cells have until recently been divided into two broad classes: channels that participate in the generation of the action potential and channels that generate postsynaptic potentials in response to neurotransmitters. This distinction was based to a large extent on the classic analysis of the action of acetylcholine (ACh) at the frog neuromuscular junction31 — where the cholinergic end-plate channels are different from the Hodgkin-Huxley Na+ and K+ channels that generate the action potential62. However, recent results suggest that in many other systems neurotransmitters can modulate the activity of channels that contribute to the action potential. This type of postsynaptic effect is responsible for several important physiological actions of transmitters43. Patch-clamp experiments provide insights into the mechanisms of modulation at the level of single-channel molecules." @default.
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- W2002021305 date "1983-01-01" @default.
- W2002021305 modified "2023-10-17" @default.
- W2002021305 title "Modulation of gated ion channels as a mode of transmitter action" @default.
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- W2002021305 doi "https://doi.org/10.1016/0166-2236(83)90145-5" @default.
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