FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002022126> ?p ?o ?g. }

• W2002022126 endingPage "1918" @default.
• W2002022126 startingPage "1914" @default.
• W2002022126 abstract "Background —It is a widely held view that congenital heart block (CHB) is caused by the transplacental transfer of maternal autoantibodies (anti-SSA/Ro and/or anti-SSB/La) into the fetal circulation. To test this hypothesis and to reproduce human CHB, an experimental mouse model ( BALB/c) was developed by passive transfer of human autoantibodies into pregnant mice. Methods and Results —Timed pregnant mice (n=54) were injected with a single intravenous bolus of purified IgG containing human anti-SSA/Ro and anti-SSB/La antibodies from mothers of children with CHB. To parallel the “window period” of susceptibility to CHB in humans, 3 groups of mice were used: 8, 11, and 16 days of gestation. Within each group, we tested 10, 25, 50, and 100 μg of IgG. At delivery, ECGs were recorded and analyzed for conduction abnormalities. Bradycardia and PR interval were significantly increased in 8-, 11-, and 16-day gestational groups when compared with controls ( P <0.05). QRS duration was not significantly different between all groups. Antibody levels measured by ELISA in both mothers and their offspring confirmed the transplacental transfer of the human antibodies to the pups. Conclusions —The passive transfer model demonstrated bradycardia, first-degree but not complete atrioventricular block in pups. The greater percentage and degree of bradycardia and PR prolongation in the 11-day mouse group correlates with the “window period” of susceptibility observed in humans. The high incidence of bradycardia suggests possible sinoatrial node involvement. All together, these data provide relevant insights into the pathogenesis of CHB." @default.
• W2002022126 created "2016-06-24" @default.
• W2002022126 creator A5020010287 @default.
• W2002022126 creator A5060472274 @default.
• W2002022126 creator A5072473587 @default.
• W2002022126 creator A5073258474 @default.
• W2002022126 date "1999-04-13" @default.
• W2002022126 modified "2023-10-18" @default.
• W2002022126 title "Electrocardiographic Abnormalities in a Murine Model Injected With IgG From Mothers of Children With Congenital Heart Block" @default.
• W2002022126 cites W1571885788 @default.
• W2002022126 cites W1973449609 @default.
• W2002022126 cites W1977798629 @default.
• W2002022126 cites W2005478031 @default.
• W2002022126 cites W2021390035 @default.
• W2002022126 cites W2025825307 @default.
• W2002022126 cites W2044625734 @default.
• W2002022126 cites W2058176160 @default.
• W2002022126 cites W2058336420 @default.
• W2002022126 cites W2068794665 @default.
• W2002022126 cites W2072350018 @default.
• W2002022126 cites W2077079333 @default.
• W2002022126 cites W2079355126 @default.
• W2002022126 cites W2094218971 @default.
• W2002022126 cites W2099707359 @default.
• W2002022126 cites W2142562469 @default.
• W2002022126 cites W2143130157 @default.
• W2002022126 cites W2321533542 @default.
• W2002022126 cites W4211009590 @default.
• W2002022126 doi "https://doi.org/10.1161/01.cir.99.14.1914" @default.
• W2002022126 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10199891" @default.
• W2002022126 hasPublicationYear "1999" @default.
• W2002022126 type Work @default.
• W2002022126 sameAs 2002022126 @default.
• W2002022126 citedByCount "82" @default.
• W2002022126 countsByYear W20020221262012 @default.
• W2002022126 countsByYear W20020221262013 @default.
• W2002022126 countsByYear W20020221262014 @default.
• W2002022126 countsByYear W20020221262015 @default.
• W2002022126 countsByYear W20020221262016 @default.
• W2002022126 countsByYear W20020221262017 @default.
• W2002022126 countsByYear W20020221262019 @default.
• W2002022126 countsByYear W20020221262020 @default.
• W2002022126 countsByYear W20020221262021 @default.
• W2002022126 countsByYear W20020221262023 @default.
• W2002022126 crossrefType "journal-article" @default.
• W2002022126 hasAuthorship W2002022126A5020010287 @default.
• W2002022126 hasAuthorship W2002022126A5060472274 @default.
• W2002022126 hasAuthorship W2002022126A5072473587 @default.
• W2002022126 hasAuthorship W2002022126A5073258474 @default.
• W2002022126 hasBestOaLocation W20020221261 @default.
• W2002022126 hasConcept C112672928 @default.
• W2002022126 hasConcept C126322002 @default.
• W2002022126 hasConcept C134018914 @default.
• W2002022126 hasConcept C159654299 @default.
• W2002022126 hasConcept C172680121 @default.
• W2002022126 hasConcept C178697064 @default.
• W2002022126 hasConcept C203014093 @default.
• W2002022126 hasConcept C2776024998 @default.
• W2002022126 hasConcept C2776661526 @default.
• W2002022126 hasConcept C2776953305 @default.
• W2002022126 hasConcept C2777495988 @default.
• W2002022126 hasConcept C2777953023 @default.
• W2002022126 hasConcept C2778376644 @default.
• W2002022126 hasConcept C2779234561 @default.
• W2002022126 hasConcept C2779906218 @default.
• W2002022126 hasConcept C2780040984 @default.
• W2002022126 hasConcept C2780283014 @default.
• W2002022126 hasConcept C46973012 @default.
• W2002022126 hasConcept C54355233 @default.
• W2002022126 hasConcept C71924100 @default.
• W2002022126 hasConcept C84393581 @default.
• W2002022126 hasConcept C86803240 @default.
• W2002022126 hasConceptScore W2002022126C112672928 @default.
• W2002022126 hasConceptScore W2002022126C126322002 @default.
• W2002022126 hasConceptScore W2002022126C134018914 @default.
• W2002022126 hasConceptScore W2002022126C159654299 @default.
• W2002022126 hasConceptScore W2002022126C172680121 @default.
• W2002022126 hasConceptScore W2002022126C178697064 @default.
• W2002022126 hasConceptScore W2002022126C203014093 @default.
• W2002022126 hasConceptScore W2002022126C2776024998 @default.
• W2002022126 hasConceptScore W2002022126C2776661526 @default.
• W2002022126 hasConceptScore W2002022126C2776953305 @default.
• W2002022126 hasConceptScore W2002022126C2777495988 @default.
• W2002022126 hasConceptScore W2002022126C2777953023 @default.
• W2002022126 hasConceptScore W2002022126C2778376644 @default.
• W2002022126 hasConceptScore W2002022126C2779234561 @default.
• W2002022126 hasConceptScore W2002022126C2779906218 @default.
• W2002022126 hasConceptScore W2002022126C2780040984 @default.
• W2002022126 hasConceptScore W2002022126C2780283014 @default.
• W2002022126 hasConceptScore W2002022126C46973012 @default.
• W2002022126 hasConceptScore W2002022126C54355233 @default.
• W2002022126 hasConceptScore W2002022126C71924100 @default.
• W2002022126 hasConceptScore W2002022126C84393581 @default.
• W2002022126 hasConceptScore W2002022126C86803240 @default.
• W2002022126 hasIssue "14" @default.
• W2002022126 hasLocation W20020221261 @default.
• W2002022126 hasLocation W20020221262 @default.
• W2002022126 hasOpenAccess W2002022126 @default.

• next