FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002022996> ?p ?o ?g. }

• W2002022996 endingPage "5899" @default.
• W2002022996 startingPage "5893" @default.
• W2002022996 abstract "Hospital-acquired (nosocomial) infection (HAI) represents a serious threat to public health, both in terms of human casualty and in terms of economic impact. On an annual basis, 2 million individuals require prolonged hospitalization, and an estimated 90 000 patients die due to HAI. Economic damages are reported to exceed $4.5 billion, annually. While many disinfectants, including peracetic acid, have been employed to eradicate infectious bacteria, a lack of understanding their mode of action and the corresponding defense mechanisms hinders successful antimicrobial application. We report here the first transcriptome analysis of the response of Pseudomonas aeruginosa, a pathogen infecting those with cystic fibrosis, upon 20 min exposure to a sublethal concentration (1 mM) of peracetic acid. As a result, we identified that 570 out of a total of 5570 P. aeruginosa genes showed statistically significant transcript level changes. Our findings indicate that (i) many genes associated with cellular protective processes were induced, (ii) the transcription of genes involved in primary metabolic pathways was repressed, and (iii) the transcription of genes encoding membrane proteins and small molecule transporters was altered. We also observed that genes within operons were highly cotranscribed in this study. Finally, this global transcriptional profile can help identify signature genes that are also activated with other oxidative disinfectants, which may be used to design new more effective treatments or more efficaciously apply existing compounds." @default.
• W2002022996 created "2016-06-24" @default.
• W2002022996 creator A5027095675 @default.
• W2002022996 creator A5028186014 @default.
• W2002022996 creator A5059506083 @default.
• W2002022996 creator A5078265259 @default.
• W2002022996 date "2005-07-02" @default.
• W2002022996 modified "2023-10-14" @default.
• W2002022996 title "Microarray Analysis of Toxicogenomic Effects of Peracetic Acid on <i>Pseudomonas aeruginosa</i>" @default.
• W2002022996 cites W121021299 @default.
• W2002022996 cites W1716100151 @default.
• W2002022996 cites W1922669508 @default.
• W2002022996 cites W1958512527 @default.
• W2002022996 cites W1981166602 @default.
• W2002022996 cites W1984685329 @default.
• W2002022996 cites W2001055223 @default.
• W2002022996 cites W2004668209 @default.
• W2002022996 cites W2046654549 @default.
• W2002022996 cites W2061878956 @default.
• W2002022996 cites W2086166570 @default.
• W2002022996 cites W2097438562 @default.
• W2002022996 cites W2104189450 @default.
• W2002022996 cites W2108244474 @default.
• W2002022996 cites W2109870018 @default.
• W2002022996 cites W2110035347 @default.
• W2002022996 cites W2112847958 @default.
• W2002022996 cites W2114769323 @default.
• W2002022996 cites W2117323214 @default.
• W2002022996 cites W2118232717 @default.
• W2002022996 cites W2128996981 @default.
• W2002022996 cites W2130249921 @default.
• W2002022996 cites W2134807272 @default.
• W2002022996 cites W2135465392 @default.
• W2002022996 cites W2137448061 @default.
• W2002022996 cites W2148641391 @default.
• W2002022996 cites W2148685325 @default.
• W2002022996 cites W2149353640 @default.
• W2002022996 cites W2159870607 @default.
• W2002022996 cites W2160613247 @default.
• W2002022996 cites W2322091504 @default.
• W2002022996 cites W3021129713 @default.
• W2002022996 cites W4234330775 @default.
• W2002022996 doi "https://doi.org/10.1021/es0503534" @default.
• W2002022996 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16124331" @default.
• W2002022996 hasPublicationYear "2005" @default.
• W2002022996 type Work @default.
• W2002022996 sameAs 2002022996 @default.
• W2002022996 citedByCount "38" @default.
• W2002022996 countsByYear W20020229962012 @default.
• W2002022996 countsByYear W20020229962013 @default.
• W2002022996 countsByYear W20020229962014 @default.
• W2002022996 countsByYear W20020229962015 @default.
• W2002022996 countsByYear W20020229962016 @default.
• W2002022996 countsByYear W20020229962018 @default.
• W2002022996 countsByYear W20020229962019 @default.
• W2002022996 countsByYear W20020229962020 @default.
• W2002022996 countsByYear W20020229962021 @default.
• W2002022996 countsByYear W20020229962022 @default.
• W2002022996 crossrefType "journal-article" @default.
• W2002022996 hasAuthorship W2002022996A5027095675 @default.
• W2002022996 hasAuthorship W2002022996A5028186014 @default.
• W2002022996 hasAuthorship W2002022996A5059506083 @default.
• W2002022996 hasAuthorship W2002022996A5078265259 @default.
• W2002022996 hasConcept C104317684 @default.
• W2002022996 hasConcept C121587506 @default.
• W2002022996 hasConcept C138885662 @default.
• W2002022996 hasConcept C150194340 @default.
• W2002022996 hasConcept C162317418 @default.
• W2002022996 hasConcept C178790620 @default.
• W2002022996 hasConcept C179926584 @default.
• W2002022996 hasConcept C185592680 @default.
• W2002022996 hasConcept C203075996 @default.
• W2002022996 hasConcept C2777309684 @default.
• W2002022996 hasConcept C2777637488 @default.
• W2002022996 hasConcept C2781221799 @default.
• W2002022996 hasConcept C41895202 @default.
• W2002022996 hasConcept C4937899 @default.
• W2002022996 hasConcept C523546767 @default.
• W2002022996 hasConcept C533411734 @default.
• W2002022996 hasConcept C54355233 @default.
• W2002022996 hasConcept C547475151 @default.
• W2002022996 hasConcept C55493867 @default.
• W2002022996 hasConcept C70721500 @default.
• W2002022996 hasConcept C8415881 @default.
• W2002022996 hasConcept C86803240 @default.
• W2002022996 hasConcept C89423630 @default.
• W2002022996 hasConcept C95371953 @default.
• W2002022996 hasConceptScore W2002022996C104317684 @default.
• W2002022996 hasConceptScore W2002022996C121587506 @default.
• W2002022996 hasConceptScore W2002022996C138885662 @default.
• W2002022996 hasConceptScore W2002022996C150194340 @default.
• W2002022996 hasConceptScore W2002022996C162317418 @default.
• W2002022996 hasConceptScore W2002022996C178790620 @default.
• W2002022996 hasConceptScore W2002022996C179926584 @default.
• W2002022996 hasConceptScore W2002022996C185592680 @default.
• W2002022996 hasConceptScore W2002022996C203075996 @default.
• W2002022996 hasConceptScore W2002022996C2777309684 @default.
• W2002022996 hasConceptScore W2002022996C2777637488 @default.

• next