FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002024809> ?p ?o ?g. }

• W2002024809 endingPage "341" @default.
• W2002024809 startingPage "337" @default.
• W2002024809 abstract "To assess associations between the activity of hypothalamo-pituitary-adrenal (HPA) axis and liver histology in patients with nonalcoholic fatty liver disease (NAFLD).In a cross-sectional study, we enrolled 50 consecutive, overweight, NAFLD patients and 40 control subjects who were comparable for age, sex and body mass index (BMI).NAFLD (by liver biopsy), HPA axis activity (by 24-hour urinary free cortisol [UFC] excretion and serum cortisol levels after 1 mg dexamethasone), insulin resistance (by homeostasis model assessment: HOMA-IR), and metabolic syndrome (MetS) features.NAFLD patients had markedly higher (P < 0.001) 24-h UFC (149 +/- 24 vs. 90 +/- 16 nmol/day) and postdex suppression cortisol concentrations (32 +/- 10 vs. 16 +/- 7 nmol/l) than controls. The MetS and its individual components were more frequent among NAFLD patients. The marked differences in urinary/serum cortisol concentrations that were observed between the groups were little affected by adjustment for age, sex, BMI, waist circumference, systolic blood pressure, triglycerides, homeostasis model assessment for insulin resistance score and presence of diabetes. Importantly, 24-h UFC and postdex cortisol concentrations strongly correlated to hepatic necroinflammatory grade (P < 0.01) and fibrosis stage (P < 0.001) among NAFLD patients. By logistic regression analysis, 24-h UFC (odds ratio (OR) 1.80, 95%CI 1.3-2.8) or postdex cortisol concentrations (OR 1.95, 95%CI 1.4-3.1) independently predicted the severity of hepatic fibrosis, but not necroinflammation, after adjustment for potential confounders.These results suggest that NAFLD patients have a subtle, chronic overactivity in the HPA axis (that is closely associated with the severity of liver histopathology) leading to subclinical hypercortisolism that might be implicated in the development of NAFLD." @default.
• W2002024809 created "2016-06-24" @default.
• W2002024809 creator A5025171819 @default.
• W2002024809 creator A5048759251 @default.
• W2002024809 creator A5071075382 @default.
• W2002024809 creator A5083367372 @default.
• W2002024809 creator A5084120800 @default.
• W2002024809 creator A5090020886 @default.
• W2002024809 date "2006-03-01" @default.
• W2002024809 modified "2023-10-01" @default.
• W2002024809 title "Associations between liver histology and cortisol secretion in subjects with nonalcoholic fatty liver disease" @default.
• W2002024809 cites W1610975395 @default.
• W2002024809 cites W1972317154 @default.
• W2002024809 cites W1978501718 @default.
• W2002024809 cites W1979860378 @default.
• W2002024809 cites W1990955926 @default.
• W2002024809 cites W1996004606 @default.
• W2002024809 cites W2008647639 @default.
• W2002024809 cites W2038686627 @default.
• W2002024809 cites W2040109162 @default.
• W2002024809 cites W2051051060 @default.
• W2002024809 cites W2056699745 @default.
• W2002024809 cites W2061962280 @default.
• W2002024809 cites W2072962624 @default.
• W2002024809 cites W2087829753 @default.
• W2002024809 cites W2092020543 @default.
• W2002024809 cites W2107267410 @default.
• W2002024809 cites W2109095584 @default.
• W2002024809 cites W2117268230 @default.
• W2002024809 cites W2129546749 @default.
• W2002024809 cites W2165136942 @default.
• W2002024809 cites W2401235370 @default.
• W2002024809 cites W4237534894 @default.
• W2002024809 cites W4238251256 @default.
• W2002024809 cites W4242799220 @default.
• W2002024809 doi "https://doi.org/10.1111/j.1365-2265.2006.02466.x" @default.
• W2002024809 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16487446" @default.
• W2002024809 hasPublicationYear "2006" @default.
• W2002024809 type Work @default.
• W2002024809 sameAs 2002024809 @default.
• W2002024809 citedByCount "84" @default.
• W2002024809 countsByYear W20020248092012 @default.
• W2002024809 countsByYear W20020248092013 @default.
• W2002024809 countsByYear W20020248092014 @default.
• W2002024809 countsByYear W20020248092015 @default.
• W2002024809 countsByYear W20020248092016 @default.
• W2002024809 countsByYear W20020248092017 @default.
• W2002024809 countsByYear W20020248092018 @default.
• W2002024809 countsByYear W20020248092019 @default.
• W2002024809 countsByYear W20020248092020 @default.
• W2002024809 countsByYear W20020248092021 @default.
• W2002024809 countsByYear W20020248092022 @default.
• W2002024809 countsByYear W20020248092023 @default.
• W2002024809 crossrefType "journal-article" @default.
• W2002024809 hasAuthorship W2002024809A5025171819 @default.
• W2002024809 hasAuthorship W2002024809A5048759251 @default.
• W2002024809 hasAuthorship W2002024809A5071075382 @default.
• W2002024809 hasAuthorship W2002024809A5083367372 @default.
• W2002024809 hasAuthorship W2002024809A5084120800 @default.
• W2002024809 hasAuthorship W2002024809A5090020886 @default.
• W2002024809 hasConcept C126322002 @default.
• W2002024809 hasConcept C134018914 @default.
• W2002024809 hasConcept C2776954865 @default.
• W2002024809 hasConcept C2777391703 @default.
• W2002024809 hasConcept C2778772119 @default.
• W2002024809 hasConcept C2779134260 @default.
• W2002024809 hasConcept C2780221984 @default.
• W2002024809 hasConcept C2780578515 @default.
• W2002024809 hasConcept C511355011 @default.
• W2002024809 hasConcept C71924100 @default.
• W2002024809 hasConceptScore W2002024809C126322002 @default.
• W2002024809 hasConceptScore W2002024809C134018914 @default.
• W2002024809 hasConceptScore W2002024809C2776954865 @default.
• W2002024809 hasConceptScore W2002024809C2777391703 @default.
• W2002024809 hasConceptScore W2002024809C2778772119 @default.
• W2002024809 hasConceptScore W2002024809C2779134260 @default.
• W2002024809 hasConceptScore W2002024809C2780221984 @default.
• W2002024809 hasConceptScore W2002024809C2780578515 @default.
• W2002024809 hasConceptScore W2002024809C511355011 @default.
• W2002024809 hasConceptScore W2002024809C71924100 @default.
• W2002024809 hasIssue "3" @default.
• W2002024809 hasLocation W20020248091 @default.
• W2002024809 hasLocation W20020248092 @default.
• W2002024809 hasOpenAccess W2002024809 @default.
• W2002024809 hasPrimaryLocation W20020248091 @default.
• W2002024809 hasRelatedWork W1973256449 @default.
• W2002024809 hasRelatedWork W1998434356 @default.
• W2002024809 hasRelatedWork W2044823377 @default.
• W2002024809 hasRelatedWork W2099963971 @default.
• W2002024809 hasRelatedWork W2124038922 @default.
• W2002024809 hasRelatedWork W2171538978 @default.
• W2002024809 hasRelatedWork W2364374092 @default.
• W2002024809 hasRelatedWork W2384987244 @default.
• W2002024809 hasRelatedWork W2390939806 @default.
• W2002024809 hasRelatedWork W4285586289 @default.
• W2002024809 hasVolume "64" @default.
• W2002024809 isParatext "false" @default.
• W2002024809 isRetracted "false" @default.

• next