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• W2002025020 abstract "This paper presents an aquatic ecological risk assessment, including an aquatic effects assessment, an exposure assessment, and a characterization of risk to aquatic organisms. In a number of acute and chronic studies with several aquatic species, octamethylcyclotetrasiloxane (OMCTS) toxicity was observed, but only after extended, continuous exposures of 7 to 14 d; survival was the only biological end point affected. The symptoms of toxicity observed were highly consistent with narcosis as the mechanism of action. For all aquatic toxicity testing, the lowest NOEC was 4.4 μg/L for rainbow trout in both 14-d and 90-d tests. The physicochemical characteristics of OMCTS (low solubility, high Kow, and very high Henry's law constant) indicate that the water concentrations should be low and transient, consistent with results of environmental-fate studies that demonstrate that OMCTS moves rapidly out of water. The primary route of release of OMCTS to the environment is associated with use in personal-care products, which would potentially result in release to air and water via public sewer systems. Environmental-fate models predict low concentrations of OMCTS in air and water. Monitoring studies indicate mean measured concentrations of OMCTS in sewage treatment plant effluents of 0.06 to 0.41 μg/L. Assuming 50% bioavailability of OMCTS and a dilution factor of three, calculated mean concentrations of dissolved OMCTS in surface waters range from 0.01 to 0.068 μg/L. Comparison of the lowest no-observed-effect concentration (NOEC) from all toxicity testing with this predicted range of surface water concentrations indicates a conservative margin of safety to 64 to 444 for aquatic organisms. Rapid volatilization and additional dilution in most aquatic environments will increase this margin of safety even further. Based on all available evidence, the risk of OMCTS to aquatic ecosystems is characterized as very low." @default.
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• W2002025020 title "Octamethylcyclotetrasiloxane (OMCTS), a case study: Summary and aquatic risk assessment" @default.
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