FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002025802> ?p ?o ?g. }

• W2002025802 endingPage "5707" @default.
• W2002025802 startingPage "5703" @default.
• W2002025802 abstract "Among the 14 human isozymes of carbonic anhydrase (CA, EC 4.2.1.1) presently known, the cytosolic hCA II is the most active and plays a host of physiological functions, whereas the mitochondrial hCA V is unique due to its role in several biosynthetic reactions. An inhibition study of these isozymes with a series of sulfonamides is reported here, with the scope to detect lead molecules for the design of isozyme-specific CA inhibitors (CAIs) targeting the mitochondrial isoform. Indeed, recently it has been shown that CA V is a novel target for the drug design of anti-obesity agents among others. Compounds included in this study were mainly ortho-, meta-, and para-substituted-benzenesulfonamides, together with several halogeno-substituted sulfanilamides and disubstituted-benzene-1,3-disulfonamide derivatives. Isozyme V showed an inhibition profile with these sulfonamides different of that of hCA II. Thus, IC50 values in the range of 80 nM to 74 μM against hCA II, and 0.78–63.7 μM against hCA V with these derivatives have been obtained. Only one compound, 2-carboxymethyl-benzenesulfonamide, was more active against hCA V over hCA II (selectivity ratio of 1.39), whereas all other derivatives investigated here were much better hCA II inhibitors (selectivity ratios CA II/CA V in the range of 0.0008–0.73) than hCA V inhibitors." @default.
• W2002025802 created "2016-06-24" @default.
• W2002025802 creator A5012797490 @default.
• W2002025802 creator A5027722233 @default.
• W2002025802 creator A5035013697 @default.
• W2002025802 creator A5054671725 @default.
• W2002025802 creator A5066383222 @default.
• W2002025802 date "2004-11-01" @default.
• W2002025802 modified "2023-09-27" @default.
• W2002025802 title "Carbonic anhydrase inhibitors: inhibition of human cytosolic isozyme II and mitochondrial isozyme V with a series of benzene sulfonamide derivatives" @default.
• W2002025802 cites W1549224984 @default.
• W2002025802 cites W1573899446 @default.
• W2002025802 cites W1606654278 @default.
• W2002025802 cites W1843300456 @default.
• W2002025802 cites W1924798630 @default.
• W2002025802 cites W1970259861 @default.
• W2002025802 cites W1979067061 @default.
• W2002025802 cites W1985615649 @default.
• W2002025802 cites W1988539482 @default.
• W2002025802 cites W1994646909 @default.
• W2002025802 cites W2022203610 @default.
• W2002025802 cites W2025001185 @default.
• W2002025802 cites W2029953509 @default.
• W2002025802 cites W2031808408 @default.
• W2002025802 cites W2034233153 @default.
• W2002025802 cites W2050046796 @default.
• W2002025802 cites W2106688214 @default.
• W2002025802 cites W2119482876 @default.
• W2002025802 cites W2120992330 @default.
• W2002025802 cites W2128090435 @default.
• W2002025802 cites W2128282008 @default.
• W2002025802 cites W2165525499 @default.
• W2002025802 cites W2226928057 @default.
• W2002025802 cites W2336457379 @default.
• W2002025802 cites W2397681412 @default.
• W2002025802 cites W2408220061 @default.
• W2002025802 cites W2951754707 @default.
• W2002025802 cites W4376849759 @default.
• W2002025802 doi "https://doi.org/10.1016/j.bmcl.2004.07.085" @default.
• W2002025802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15482952" @default.
• W2002025802 hasPublicationYear "2004" @default.
• W2002025802 type Work @default.
• W2002025802 sameAs 2002025802 @default.
• W2002025802 citedByCount "15" @default.
• W2002025802 countsByYear W20020258022015 @default.
• W2002025802 countsByYear W20020258022016 @default.
• W2002025802 countsByYear W20020258022018 @default.
• W2002025802 countsByYear W20020258022023 @default.
• W2002025802 crossrefType "journal-article" @default.
• W2002025802 hasAuthorship W2002025802A5012797490 @default.
• W2002025802 hasAuthorship W2002025802A5027722233 @default.
• W2002025802 hasAuthorship W2002025802A5035013697 @default.
• W2002025802 hasAuthorship W2002025802A5054671725 @default.
• W2002025802 hasAuthorship W2002025802A5066383222 @default.
• W2002025802 hasConcept C104317684 @default.
• W2002025802 hasConcept C118792377 @default.
• W2002025802 hasConcept C119795356 @default.
• W2002025802 hasConcept C161790260 @default.
• W2002025802 hasConcept C181199279 @default.
• W2002025802 hasConcept C185592680 @default.
• W2002025802 hasConcept C2775914622 @default.
• W2002025802 hasConcept C2776980637 @default.
• W2002025802 hasConcept C2780416268 @default.
• W2002025802 hasConcept C2781039511 @default.
• W2002025802 hasConcept C2911210155 @default.
• W2002025802 hasConcept C53345823 @default.
• W2002025802 hasConcept C55493867 @default.
• W2002025802 hasConcept C71240020 @default.
• W2002025802 hasConcept C98539663 @default.
• W2002025802 hasConceptScore W2002025802C104317684 @default.
• W2002025802 hasConceptScore W2002025802C118792377 @default.
• W2002025802 hasConceptScore W2002025802C119795356 @default.
• W2002025802 hasConceptScore W2002025802C161790260 @default.
• W2002025802 hasConceptScore W2002025802C181199279 @default.
• W2002025802 hasConceptScore W2002025802C185592680 @default.
• W2002025802 hasConceptScore W2002025802C2775914622 @default.
• W2002025802 hasConceptScore W2002025802C2776980637 @default.
• W2002025802 hasConceptScore W2002025802C2780416268 @default.
• W2002025802 hasConceptScore W2002025802C2781039511 @default.
• W2002025802 hasConceptScore W2002025802C2911210155 @default.
• W2002025802 hasConceptScore W2002025802C53345823 @default.
• W2002025802 hasConceptScore W2002025802C55493867 @default.
• W2002025802 hasConceptScore W2002025802C71240020 @default.
• W2002025802 hasConceptScore W2002025802C98539663 @default.
• W2002025802 hasIssue "22" @default.
• W2002025802 hasLocation W20020258021 @default.
• W2002025802 hasLocation W20020258022 @default.
• W2002025802 hasOpenAccess W2002025802 @default.
• W2002025802 hasPrimaryLocation W20020258021 @default.
• W2002025802 hasRelatedWork W2000584792 @default.
• W2002025802 hasRelatedWork W2030627791 @default.
• W2002025802 hasRelatedWork W2054838817 @default.
• W2002025802 hasRelatedWork W2080860795 @default.
• W2002025802 hasRelatedWork W2116533349 @default.
• W2002025802 hasRelatedWork W2131861685 @default.
• W2002025802 hasRelatedWork W264945370 @default.
• W2002025802 hasRelatedWork W2896867935 @default.
• W2002025802 hasRelatedWork W3017200123 @default.

• next