Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002029199> ?p ?o ?g. }
- W2002029199 endingPage "155" @default.
- W2002029199 startingPage "147" @default.
- W2002029199 abstract "Perinatal transmission of Human immunodeficiency virus (HIV), also called mother-to-child transmission (MTCT), accounts for 90% of infections in infants worldwide and occurs in 30%-45% of children born to untreated HIV-1 infected mothers. Among HIV-1 infected mothers, some viruses are transmitted from mothers to their infants while others are not. The relationship between virologic properties and the pathogenesis caused by HIV-1 remains unclear. Previous studies have demonstrated that one obvious source of selective pressure in the perinatal transmission of HIV-1 is maternal neutralizing antibodies. Recent studies have shown that viruses which are successfully transmitted to the child have growth advantages over those not transmitted, when those two viruses are grown together. Furthermore, the higher fitness is determined by the gp120 protein of the virus envelope. This suggests that the selective transmission of viruses with higher fitness occurred exclusively, regardless of transmission routes. There are many factors contributing to the selective transmission and HIV replicative fitness is an important one that should not be neglected. This review summarizes current knowledge of the role of HIV replicative fitness in HIV MTCT transmission and the determinants of viral fitness upon MTCT." @default.
- W2002029199 created "2016-06-24" @default.
- W2002029199 creator A5004211599 @default.
- W2002029199 creator A5022256556 @default.
- W2002029199 creator A5090859256 @default.
- W2002029199 date "2011-06-01" @default.
- W2002029199 modified "2023-10-14" @default.
- W2002029199 title "The role of HIV replicative fitness in perinatal transmission of HIV" @default.
- W2002029199 cites W145537095 @default.
- W2002029199 cites W1965563114 @default.
- W2002029199 cites W1966261980 @default.
- W2002029199 cites W1996693962 @default.
- W2002029199 cites W1997401598 @default.
- W2002029199 cites W1997585759 @default.
- W2002029199 cites W2003141469 @default.
- W2002029199 cites W2004943035 @default.
- W2002029199 cites W2011630381 @default.
- W2002029199 cites W2015679076 @default.
- W2002029199 cites W2018010836 @default.
- W2002029199 cites W2023479104 @default.
- W2002029199 cites W2023923364 @default.
- W2002029199 cites W2027499205 @default.
- W2002029199 cites W2030844138 @default.
- W2002029199 cites W2040698214 @default.
- W2002029199 cites W2042762456 @default.
- W2002029199 cites W2047519810 @default.
- W2002029199 cites W2060076927 @default.
- W2002029199 cites W2065341140 @default.
- W2002029199 cites W2066354913 @default.
- W2002029199 cites W2068253484 @default.
- W2002029199 cites W2081049348 @default.
- W2002029199 cites W2081885109 @default.
- W2002029199 cites W2084197987 @default.
- W2002029199 cites W2086044183 @default.
- W2002029199 cites W2087183768 @default.
- W2002029199 cites W2102674010 @default.
- W2002029199 cites W2104802051 @default.
- W2002029199 cites W2106968631 @default.
- W2002029199 cites W2107483934 @default.
- W2002029199 cites W2110011873 @default.
- W2002029199 cites W2110340634 @default.
- W2002029199 cites W2124039449 @default.
- W2002029199 cites W2128868625 @default.
- W2002029199 cites W2131609238 @default.
- W2002029199 cites W2132294598 @default.
- W2002029199 cites W2137671068 @default.
- W2002029199 cites W2139777184 @default.
- W2002029199 cites W2143437486 @default.
- W2002029199 cites W2144539981 @default.
- W2002029199 cites W2145578434 @default.
- W2002029199 cites W2147413871 @default.
- W2002029199 cites W2154482881 @default.
- W2002029199 cites W2157644226 @default.
- W2002029199 cites W2162193497 @default.
- W2002029199 cites W2165657851 @default.
- W2002029199 cites W2166237809 @default.
- W2002029199 cites W2167983396 @default.
- W2002029199 cites W2326939749 @default.
- W2002029199 cites W2331226049 @default.
- W2002029199 cites W2602284652 @default.
- W2002029199 cites W4293052483 @default.
- W2002029199 doi "https://doi.org/10.1007/s12250-011-3180-2" @default.
- W2002029199 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8222459" @default.
- W2002029199 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21667335" @default.
- W2002029199 hasPublicationYear "2011" @default.
- W2002029199 type Work @default.
- W2002029199 sameAs 2002029199 @default.
- W2002029199 citedByCount "3" @default.
- W2002029199 countsByYear W20020291992016 @default.
- W2002029199 countsByYear W20020291992018 @default.
- W2002029199 countsByYear W20020291992023 @default.
- W2002029199 crossrefType "journal-article" @default.
- W2002029199 hasAuthorship W2002029199A5004211599 @default.
- W2002029199 hasAuthorship W2002029199A5022256556 @default.
- W2002029199 hasAuthorship W2002029199A5090859256 @default.
- W2002029199 hasBestOaLocation W20020291992 @default.
- W2002029199 hasConcept C119599485 @default.
- W2002029199 hasConcept C127413603 @default.
- W2002029199 hasConcept C159047783 @default.
- W2002029199 hasConcept C203014093 @default.
- W2002029199 hasConcept C2522874641 @default.
- W2002029199 hasConcept C3013748606 @default.
- W2002029199 hasConcept C71924100 @default.
- W2002029199 hasConcept C761482 @default.
- W2002029199 hasConcept C86803240 @default.
- W2002029199 hasConceptScore W2002029199C119599485 @default.
- W2002029199 hasConceptScore W2002029199C127413603 @default.
- W2002029199 hasConceptScore W2002029199C159047783 @default.
- W2002029199 hasConceptScore W2002029199C203014093 @default.
- W2002029199 hasConceptScore W2002029199C2522874641 @default.
- W2002029199 hasConceptScore W2002029199C3013748606 @default.
- W2002029199 hasConceptScore W2002029199C71924100 @default.
- W2002029199 hasConceptScore W2002029199C761482 @default.
- W2002029199 hasConceptScore W2002029199C86803240 @default.
- W2002029199 hasIssue "3" @default.
- W2002029199 hasLocation W20020291991 @default.
- W2002029199 hasLocation W20020291992 @default.
- W2002029199 hasLocation W20020291993 @default.