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- W2002030812 abstract "Neurofilament light (NFL) proteins in CSF are markers of subcortical axonal injury and have been noted to be increased in patients with AD. It is unclear if early changes in CSF NFL levels can be detected in middle -aged adults at increased risk for AD or whether such early changes are related to alterations in CSF A β and tau levels or cognitive performance. In this cross-sectional analysis, baseline CSF and cognitive data were used from 100 asymptomatic adults (ages 36–69 years) with parental history of AD participating in a randomized, controlled statin intervention trial. Simultaneous measurement of CSF A b 42, total tau (t-tau), and phosphorylated tau 181 (p-tau 181) were determined using xMAP technology. CSF NFL concentrations were analyzed using ELISA with a detection limit of 125 ng/L. A cognitive test battery emphasized measures of memory and executive function. Wilcoxon-Mann-Whitney and t-tests were used to assess group differences in biomarker and cognitive parameters. Of the 100 participants (mean [SD] age 53.5 [8.0] years, 70% women, 38% APOE4 carriers), 96 had analyzable CSF samples with 19 participants showing detectable NFL (D-NFL) levels in CSF. Compared to those with non-detectable NFL levels (ND-NFL, n=77), D-NFL participants had higher CSF t-tau (median 78.0 vs. 58.0 ng/L, p=0.005), higher p-tau 181 (mean [SD] 49.2 [21.4] vs. 34.8 [15.9] ng/L, p=0.002) (Figure) and poorer performance on WAIS-III Processing Speed Index (p=0.048). Both D-NFL and ND-NFL groups had similar CSF A β 42 levels (mean 363.7 [97.2] vs. 333.9 [75.2] ng/L, p=0.157), comparable performance on learning and memory tasks (all p>0.1), and similar vascular risk profiles. Group Differences in CSF Total Tau, P-Tau-181, and Aβ42 Levels between Participants with Detectable NFL (D-NFL) and Non-detectable NFL (ND-NFL) in CSF." @default.
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- W2002030812 date "2012-07-01" @default.
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- W2002030812 title "P4-271: CSF neurofilament light proteins and cognitive performance in middle-aged adults at increased risk for Alzheimer's disease" @default.
- W2002030812 doi "https://doi.org/10.1016/j.jalz.2013.08.052" @default.
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