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• W2002031855 abstract "We have recently reported that treatment of bovine pulmonary artery smooth muscle cells with the thromboxane A(2) mimetic, U46619 stimulated NADPH oxidase derived O(2)(·-) level, which subsequently caused marked increase in [Ca(2+)](i)[17]. Herein, we demonstrated that O(2)(·-)-mediated increase in [Ca(2+)](i) stimulates an aprotinin sensitive proteinase activity, which proteolytically activates PKC-α under U46619 treatment to the cells. The activated PKC-α then phosphorylates p(38)MAPK and that subsequently caused G(i)α phosphorylation leading to stimulation of cPLA(2) activity in the cell membrane." @default.
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• W2002031855 date "2012-07-01" @default.
• W2002031855 modified "2023-09-27" @default.
• W2002031855 title "Role of PKCα–p38MAPK–Giα axis in NADPH oxidase derived <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML altimg=si1.gif overflow=scroll><mml:mrow><mml:msubsup><mml:mrow><mml:mtext>O</mml:mtext></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow><mml:mrow><mml:mo>·</mml:mo><mml:mo>-</mml:mo></mml:mrow></mml:msubsup></mml:mrow></mml:math>-mediated activation of cPLA2 under U46619 stimulation in pulmonary artery smooth muscle cells" @default.
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• W2002031855 doi "https://doi.org/10.1016/j.abb.2012.04.017" @default.
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