FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002033794> ?p ?o ?g. }

• W2002033794 endingPage "32" @default.
• W2002033794 startingPage "25" @default.
• W2002033794 abstract "A majority of patients with bladder cancer present with superficial disease and subsequently, some patients show progression to muscle invasive or metastatic disease. Bladder cancer has a complex genetic process and identification of the genetic alterations which occur during progression may lead to the understanding of the nature of the disease and provide the possibility of early treatment. The aim of the present study was to compare the structural and numerical chromosomal differences and changes in the p16 and p53 genes between low‑grade (LG) and high‑grade (HG) bladder cancer (BC) using cytogenetic and molecular cytogenetic methods. Between March 2009 and March 2010, cytogenetic analyses were carried out on tumor and blood samples in 34 patients with transitional cell type BC, and on blood samples of 34 healthy patients as a control group. Fluorescence in situ hybridization probes for the p16 and p53 genes were also used to screen the alterations in these genes in 32 patients with BC. The patients were divided into two groups (LG and HG) and the findings were compared. A total of 11 (32.3%) patients exhibited LGBC, 22 (64.7%) exhibited HGBC and one (3%) patient exhibited carcinoma in situ. There were no differences between the LGBC and HGBC groups according to the number of chromosomal aberrations (P=0.714); however, differences between alterations of the p16 and p53 genes were significant (P=0.002 and P=0.039). Almost all structural abnormalities were found to be located to the 1q21, 1q32, 3p21 and 5q31 regions in patients with HG tumors. In conclusion, the p16 and p53 genes were altered more prominently in patients with HG tumors compared with LG tumors. The structural abnormalities in the 1q21, 1q32, 3p21 and 5q31 regions were observed more frequently in patients with HG tumors. These regions may play significant roles in the progression of BC, but further studies are required to find candidate genes for a panel of BC." @default.
• W2002033794 created "2016-06-24" @default.
• W2002033794 creator A5006839975 @default.
• W2002033794 creator A5018026134 @default.
• W2002033794 creator A5034835107 @default.
• W2002033794 creator A5035475688 @default.
• W2002033794 creator A5047152122 @default.
• W2002033794 creator A5054607541 @default.
• W2002033794 creator A5066460686 @default.
• W2002033794 creator A5086768504 @default.
• W2002033794 date "2014-05-02" @default.
• W2002033794 modified "2023-09-28" @default.
• W2002033794 title "Genetic alterations of chromosomes, p53 and p16 genes in low- and high-grade bladder cancer" @default.
• W2002033794 cites W1691536328 @default.
• W2002033794 cites W1899090394 @default.
• W2002033794 cites W1986960957 @default.
• W2002033794 cites W2000779459 @default.
• W2002033794 cites W2020523946 @default.
• W2002033794 cites W2021007225 @default.
• W2002033794 cites W2036860060 @default.
• W2002033794 cites W2049193909 @default.
• W2002033794 cites W2056035458 @default.
• W2002033794 cites W2057179294 @default.
• W2002033794 cites W2068415131 @default.
• W2002033794 cites W2069347151 @default.
• W2002033794 cites W2082462626 @default.
• W2002033794 cites W2101228818 @default.
• W2002033794 cites W2104229062 @default.
• W2002033794 cites W2106417221 @default.
• W2002033794 cites W2106787323 @default.
• W2002033794 cites W2112259205 @default.
• W2002033794 cites W2119882231 @default.
• W2002033794 cites W2137535245 @default.
• W2002033794 cites W2140178932 @default.
• W2002033794 cites W2146421363 @default.
• W2002033794 cites W2152858404 @default.
• W2002033794 cites W2169904237 @default.
• W2002033794 cites W2172097912 @default.
• W2002033794 cites W2322769851 @default.
• W2002033794 cites W2324890938 @default.
• W2002033794 cites W986195926 @default.
• W2002033794 doi "https://doi.org/10.3892/ol.2014.2108" @default.
• W2002033794 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4063627" @default.
• W2002033794 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24959214" @default.
• W2002033794 hasPublicationYear "2014" @default.
• W2002033794 type Work @default.
• W2002033794 sameAs 2002033794 @default.
• W2002033794 citedByCount "17" @default.
• W2002033794 countsByYear W20020337942015 @default.
• W2002033794 countsByYear W20020337942016 @default.
• W2002033794 countsByYear W20020337942017 @default.
• W2002033794 countsByYear W20020337942018 @default.
• W2002033794 countsByYear W20020337942019 @default.
• W2002033794 countsByYear W20020337942021 @default.
• W2002033794 countsByYear W20020337942022 @default.
• W2002033794 crossrefType "journal-article" @default.
• W2002033794 hasAuthorship W2002033794A5006839975 @default.
• W2002033794 hasAuthorship W2002033794A5018026134 @default.
• W2002033794 hasAuthorship W2002033794A5034835107 @default.
• W2002033794 hasAuthorship W2002033794A5035475688 @default.
• W2002033794 hasAuthorship W2002033794A5047152122 @default.
• W2002033794 hasAuthorship W2002033794A5054607541 @default.
• W2002033794 hasAuthorship W2002033794A5066460686 @default.
• W2002033794 hasAuthorship W2002033794A5086768504 @default.
• W2002033794 hasBestOaLocation W20020337941 @default.
• W2002033794 hasConcept C104317684 @default.
• W2002033794 hasConcept C121608353 @default.
• W2002033794 hasConcept C126322002 @default.
• W2002033794 hasConcept C142724271 @default.
• W2002033794 hasConcept C143998085 @default.
• W2002033794 hasConcept C2777542201 @default.
• W2002033794 hasConcept C2778065480 @default.
• W2002033794 hasConcept C2779134260 @default.
• W2002033794 hasConcept C2780352672 @default.
• W2002033794 hasConcept C2781018059 @default.
• W2002033794 hasConcept C29537977 @default.
• W2002033794 hasConcept C30481170 @default.
• W2002033794 hasConcept C502942594 @default.
• W2002033794 hasConcept C54355233 @default.
• W2002033794 hasConcept C67082663 @default.
• W2002033794 hasConcept C71924100 @default.
• W2002033794 hasConcept C86803240 @default.
• W2002033794 hasConceptScore W2002033794C104317684 @default.
• W2002033794 hasConceptScore W2002033794C121608353 @default.
• W2002033794 hasConceptScore W2002033794C126322002 @default.
• W2002033794 hasConceptScore W2002033794C142724271 @default.
• W2002033794 hasConceptScore W2002033794C143998085 @default.
• W2002033794 hasConceptScore W2002033794C2777542201 @default.
• W2002033794 hasConceptScore W2002033794C2778065480 @default.
• W2002033794 hasConceptScore W2002033794C2779134260 @default.
• W2002033794 hasConceptScore W2002033794C2780352672 @default.
• W2002033794 hasConceptScore W2002033794C2781018059 @default.
• W2002033794 hasConceptScore W2002033794C29537977 @default.
• W2002033794 hasConceptScore W2002033794C30481170 @default.
• W2002033794 hasConceptScore W2002033794C502942594 @default.
• W2002033794 hasConceptScore W2002033794C54355233 @default.
• W2002033794 hasConceptScore W2002033794C67082663 @default.
• W2002033794 hasConceptScore W2002033794C71924100 @default.

• next