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- W2002034630 abstract "At the 1993 annual meeting of the College on Problems of Drug Dependence in Toronto Canada, a symposium entitled ‘Cardiovascular effects of cocaine: Underlying mechanisms’ was presented. The purpose of this symposium was to present a wide range of state-ofthe-art research on the cardiovascular effects of cocaine, including both animal and human studies. The timeliness of this symposium is supported by the continued upward trends in the mentions for cocaine in the Drug Abuse Warning Network (DAWN) surveys of both emergency rooms and medical examiners. Increases in cocaine mentions have occurred in both of these surveys in each of the last two years for which data are available (1991- 1992). Undoubtedly, the cardiovascular effects of cocaine played some role in these increasing trends. The papers that follow grew out of four presentations at that symposium. The paper by Gillis et al. (1995) reviews their extensive animal research on locus of action for cocaine in producing its sympathetic nervous system mediated effects. They conclude that rather than having a central nervous system origin, the sympathetic mediated cardiovascular effects are primarily due to actions of cocaine in the periphery. While contradicted by other studies using more indirect measures of sympathetic nervous system function which have pointed to a central origin for the cardiovascular effects of cocaine (e.g., Wilkerson, 1988), the techniques used by Gillis et al. to directly measure sympathetic nerve activity presents a strong case for a peripheral site of action for cocaine. The research reviewed in the paper by Schindler et al. (1995) utilized more traditional techniques to explore the pharmacological basis for the cardiovascular effects of co" @default.
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- W2002034630 date "1995-03-01" @default.
- W2002034630 modified "2023-10-14" @default.
- W2002034630 title "Cardiovascular effects of cocaine: underlying mechanisms" @default.
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- W2002034630 doi "https://doi.org/10.1016/0376-8716(94)01084-x" @default.
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