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- W2002034912 abstract "The study of gene and protein interaction networks has improved our understanding of the multiple, systemic levels of regulation found in eukaryotic and prokaryotic organisms. Here we carry out a large-scale analysis of the protein-protein interaction (PPI) network of fission yeast (Schizosaccharomyces pombe) and establish a method to identify ‘linker’ proteins that bridge diverse cellular processes - integrating Gene Ontology and PPI data with network theory measures. We test the method on a highly characterized subset of the genome consisting of proteins controlling the cell cycle, cell polarity and cytokinesis and identify proteins likely to play a key role in controlling the temporal changes in the localization of the polarity machinery. Experimental inspection of one such factor, the polarity-regulating RNB protein Sts5, confirms the prediction that it has a cell cycle dependent regulation. Detailed bibliographic inspection of other predicted ‘linkers’ also confirms the predictive power of the method. As the method is robust to network perturbations and can successfully predict linker proteins, it provides a powerful tool to study the interplay between different cellular processes." @default.
- W2002034912 created "2016-06-24" @default.
- W2002034912 creator A5007629887 @default.
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- W2002034912 date "2012-10-18" @default.
- W2002034912 modified "2023-10-03" @default.
- W2002034912 title "Linkers of Cell Polarity and Cell Cycle Regulation in the Fission Yeast Protein Interaction Network" @default.
- W2002034912 cites W154688724 @default.
- W2002034912 cites W1546962148 @default.
- W2002034912 cites W1590250492 @default.
- W2002034912 cites W1806630989 @default.
- W2002034912 cites W1897176361 @default.
- W2002034912 cites W1906393634 @default.
- W2002034912 cites W1944970393 @default.
- W2002034912 cites W1964146094 @default.
- W2002034912 cites W1970871693 @default.
- W2002034912 cites W1974325386 @default.
- W2002034912 cites W1980086614 @default.
- W2002034912 cites W1984980345 @default.
- W2002034912 cites W1985245436 @default.
- W2002034912 cites W1986707765 @default.
- W2002034912 cites W1987144436 @default.
- W2002034912 cites W1990265320 @default.
- W2002034912 cites W1991965387 @default.
- W2002034912 cites W1991988184 @default.
- W2002034912 cites W1994306321 @default.
- W2002034912 cites W1995213405 @default.
- W2002034912 cites W1995738916 @default.
- W2002034912 cites W1997419253 @default.
- W2002034912 cites W2003132497 @default.
- W2002034912 cites W2003400615 @default.
- W2002034912 cites W2010000580 @default.
- W2002034912 cites W2010015418 @default.
- W2002034912 cites W2010371279 @default.
- W2002034912 cites W2012852001 @default.
- W2002034912 cites W2014276510 @default.
- W2002034912 cites W2020651752 @default.
- W2002034912 cites W2024233965 @default.
- W2002034912 cites W2024839376 @default.
- W2002034912 cites W2025582729 @default.
- W2002034912 cites W2030184227 @default.
- W2002034912 cites W2041280776 @default.
- W2002034912 cites W2043147257 @default.
- W2002034912 cites W2043555147 @default.
- W2002034912 cites W2045729458 @default.
- W2002034912 cites W2046049550 @default.
- W2002034912 cites W2047693963 @default.
- W2002034912 cites W2052948442 @default.
- W2002034912 cites W2056889742 @default.
- W2002034912 cites W2061683828 @default.
- W2002034912 cites W2065876736 @default.
- W2002034912 cites W2067655540 @default.
- W2002034912 cites W2068798734 @default.
- W2002034912 cites W2072720547 @default.
- W2002034912 cites W2074307550 @default.
- W2002034912 cites W2075058348 @default.
- W2002034912 cites W2075331295 @default.
- W2002034912 cites W2077672381 @default.
- W2002034912 cites W2078930619 @default.
- W2002034912 cites W2079121387 @default.
- W2002034912 cites W2082703912 @default.
- W2002034912 cites W2086209631 @default.
- W2002034912 cites W2087126960 @default.
- W2002034912 cites W2090929878 @default.
- W2002034912 cites W2091630884 @default.
- W2002034912 cites W2096253801 @default.
- W2002034912 cites W2098344918 @default.
- W2002034912 cites W2101188022 @default.
- W2002034912 cites W2103017472 @default.
- W2002034912 cites W2104028207 @default.
- W2002034912 cites W2107727333 @default.
- W2002034912 cites W2110123230 @default.
- W2002034912 cites W2113613985 @default.
- W2002034912 cites W2115868888 @default.
- W2002034912 cites W2118744058 @default.
- W2002034912 cites W2119114096 @default.
- W2002034912 cites W2120191747 @default.
- W2002034912 cites W2122712517 @default.
- W2002034912 cites W2123977090 @default.
- W2002034912 cites W2126216247 @default.
- W2002034912 cites W2127303707 @default.
- W2002034912 cites W2130458328 @default.
- W2002034912 cites W2132022337 @default.
- W2002034912 cites W2132350103 @default.
- W2002034912 cites W2133636760 @default.
- W2002034912 cites W2133809942 @default.
- W2002034912 cites W2135805255 @default.
- W2002034912 cites W2137016137 @default.
- W2002034912 cites W2141876679 @default.
- W2002034912 cites W2142501578 @default.
- W2002034912 cites W2143852028 @default.
- W2002034912 cites W2144702196 @default.