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- W2002035331 abstract "ReSTAGE 1,2 is a multi-study3,4,5,6 collaboration that draws together information provided by longitudinal studies of mid-life women that have incorporated the collection of menstrual calendars.ReSTAGE has used the menstrual calendar evidence provided by these studies to evaluate several menstrual ‘markers’ of the menopausal transition proposed in 2001 by the Stages of Reproductive Aging Workshop (STRAW)2,7. Markers are defined in terms of the intervals between consecutive dates of onset of menstrual bleeding (segments). An interval of at least 90 days is currently recognised as a marker of the late menopausal transition8. ReSTAGE recommended that the 60-day interval proposed by STRAW should be used instead of the 90-day interval as a marker of the beginning of late-stage transition1.Two other menstrual markers of entry to late stage transition considered by ReSTAGE required knowledge of a history of at least 10 of a woman’s immediately preceding segments, making them much less accessible in a clinical situation than the single-segment-dependent 60-day and 90-day markers. These other markers (running range over 42 days and ‘skipped segment’) often occurred on the same segment as the 60-day marker, and their distributions of age at first occurrence after a woman had reached age 40 were very similar to that of the 60-day marker. Among women whose final menstrual period (FMP) was observed in the four studies, 92% to 100% had experienced the 60-day marker after age 40. The corresponding percentages were very similar for the running range and skipped segment markers, but they were somewhat lower (79% to 91%) for the 90-day marker.In the context of considering markers of entry to early menopausal transition, ReSTAGE made use of the concept of the ‘persistence’ of a menstrual marker9,4. A marker is said to occur persistently, or ‘with persistence’, if it recurs within the next 10 bleeding segments following its initial occurrence. In this article we consider whether the concept of persistence can be useful in a clinical context in relation to the late-stage 60-day marker, taking into account whether or not the woman is aged under 45 years." @default.
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- W2002035331 date "2010-01-01" @default.
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- W2002035331 title "Persistence improves the 60-day amenorrhea marker of entry to late-stage menopausal transition for women aged 40 to 44 years" @default.
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- W2002035331 doi "https://doi.org/10.1097/gme.0b013e3181b5540e" @default.
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