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- W2002036224 abstract "Immunoglobulins are essential for health. In the absence of these proteins, life-threatening illnesses often occur, as evidenced by the susceptibility of people with congenital or acquired immunoglobulin deficiencies to infection or neoplasia. On the other hand, a hyperabundance of immunoglobulins can also be harmful, especially when the antibodies are directed against self-antigens (i.e., autoantibodies) or have certain physicochemical or structural properties that render them pathogenic, resulting, for example, in an immune-complex disease or hyperviscosity syndrome. Even more striking is the clinical impact of immunoglobulin overproduction in patients with plasma-cell dyscrasias in which the protein is deposited in vital organs. These . . ." @default.
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- W2002036224 date "1993-11-04" @default.
- W2002036224 modified "2023-10-17" @default.
- W2002036224 title "Ominous Consequences of Immunoglobulin Deposition" @default.
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- W2002036224 doi "https://doi.org/10.1056/nejm199311043291913" @default.
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