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- W200204023 abstract "Abstract Eight provisional groups of HLA-D specificities (MLR stimulating determinants) have been defined during the VI International Histocompatibility Workshop 1975. Each D-specificity group was defined by two or more D-locus homozygous typing cells. Population studies with the typing cells and mutual MLR between cells belonging to the same group demonstrate some differences within each D-specificity group. In this study we present data obtained with two HLA-D homozygous typing cells representing the DW4 specificity group. Both cells were included in the workshop and were shown in population studies to belong to the DW4 group. Mutual MLR between the two cells, however, is positive. The differences in the determinants expressed by these two cells are confirmed in family-studies including parents and other family members of each typing cell donor and of families unrelated to both cell donors. The typing cells homozygous for B12,DW4 shows very low typing responses when tested against some responders heterozygous for B12 while the BW15,DW4 homozygous typing cells shows the lowest typing responses to some BW15 heterozygous responders. One family is presented where both parents express a DW4 determinant. The parents show different response pattern to the two typing cells. Independent segregation of the two different DW4 is observed in the family. This data suggests that the HLA-D region may be composed of genetic subloci. The two different DW4 specificities described in this paper may express determinants on more than one locus. These determinants could, however, occur in the population in strong positive genetic linkage disequilibrium." @default.
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- W200204023 date "1976-01-01" @default.
- W200204023 modified "2023-09-27" @default.
- W200204023 title "EVIDENCE FOR SEVERAL CLOSELY LINKED GENES INVOLVED IN GENERATION OF PROLIFERATION IN MLC." @default.
- W200204023 cites W1525316287 @default.
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- W200204023 doi "https://doi.org/10.1016/b978-0-12-401660-6.50020-5" @default.
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