Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002045669> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2002045669 endingPage "347" @default.
- W2002045669 startingPage "339" @default.
- W2002045669 abstract "Objective: Vascular endothelial growth factor has been used in preclinical studies and phase 1 and 2 clinical trials as a potent mediator of therapeutic angiogenesis; however, its ability to enhance the vascular permeability may be a source of potential complications. The objective of this work was to evaluate the effects of the intramuscular injection of an adenovirus vector coding for the 121–amino acid form of vascular endothelial growth factor (Ad.VEGF121 ) on vascular permeability and edema development in rabbits and rats. Methods: Different concentrations of Ad.VEGF121 ranging from 105 to 1010 plaque-forming units/mL (3 × 106-3 × 1011 particles/mL) were injected into hind limb or forelimb muscles of Wistar rats or rabbits. The size of the scrotum, the circumferences of limbs, and the concentration of vascular endothelial growth factor in the serum were measured daily after injection. Results: The injection of different concentrations of Ad.VEGF121 into the hind limb muscles of rabbits led to a dose-dependent scrotal edema in rabbits at concentrations higher than 107 plaque-forming units/mL (P = .002). The edema developed slowly, reached its maximum level 6 days after the injection, and spontaneously resolved thereafter. At concentrations higher than 109 plaque-forming units/mL the scrotal edema was accompanied by skin necrosis (P = .0001). No scrotal edema was observed in rats. Conclusions: The massive species-specific scrotal edema accompanied by skin ulceration and necrosis was observed only in rabbits treated with Ad.VEGF121 in concentrations exceeding therapeutic doses. The therapeutic doses of Ad.VEGF121 resulted in only moderate transient scrotal edema in rabbits, suggesting that the potential for side effects of vascular endothelial growth factor therapy as a result of increased vascular permeability should not be very alarming for generally healthy patients and may not cause a significant clinical problem in the treatment of peripheral vascular diseases. (J Thorac Cardiovasc Surg 1999;118:339-47)" @default.
- W2002045669 created "2016-06-24" @default.
- W2002045669 creator A5038242144 @default.
- W2002045669 creator A5042841305 @default.
- W2002045669 creator A5045929439 @default.
- W2002045669 creator A5048926232 @default.
- W2002045669 creator A5070556276 @default.
- W2002045669 date "1999-08-01" @default.
- W2002045669 modified "2023-10-18" @default.
- W2002045669 title "Vascular permeability effect of adenovirus-mediated vascular endothelial growth factor gene transfer to the rabbit and rat skeletal muscle" @default.
- W2002045669 cites W1993526880 @default.
- W2002045669 cites W2014907034 @default.
- W2002045669 cites W2023052504 @default.
- W2002045669 cites W2030602309 @default.
- W2002045669 cites W2037141117 @default.
- W2002045669 cites W2038812679 @default.
- W2002045669 cites W2042344498 @default.
- W2002045669 cites W2044294583 @default.
- W2002045669 cites W2051659686 @default.
- W2002045669 cites W2058177351 @default.
- W2002045669 cites W2058704686 @default.
- W2002045669 cites W2061312392 @default.
- W2002045669 cites W2084582669 @default.
- W2002045669 cites W2092246905 @default.
- W2002045669 cites W2093457985 @default.
- W2002045669 cites W2105146448 @default.
- W2002045669 cites W2107309778 @default.
- W2002045669 cites W2115446927 @default.
- W2002045669 cites W2145468741 @default.
- W2002045669 doi "https://doi.org/10.1016/s0022-5223(99)70225-4" @default.
- W2002045669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10425008" @default.
- W2002045669 hasPublicationYear "1999" @default.
- W2002045669 type Work @default.
- W2002045669 sameAs 2002045669 @default.
- W2002045669 citedByCount "30" @default.
- W2002045669 countsByYear W20020456692016 @default.
- W2002045669 crossrefType "journal-article" @default.
- W2002045669 hasAuthorship W2002045669A5038242144 @default.
- W2002045669 hasAuthorship W2002045669A5042841305 @default.
- W2002045669 hasAuthorship W2002045669A5045929439 @default.
- W2002045669 hasAuthorship W2002045669A5048926232 @default.
- W2002045669 hasAuthorship W2002045669A5070556276 @default.
- W2002045669 hasBestOaLocation W20020456691 @default.
- W2002045669 hasConcept C105702510 @default.
- W2002045669 hasConcept C113045295 @default.
- W2002045669 hasConcept C126322002 @default.
- W2002045669 hasConcept C134018914 @default.
- W2002045669 hasConcept C142724271 @default.
- W2002045669 hasConcept C150903083 @default.
- W2002045669 hasConcept C167734588 @default.
- W2002045669 hasConcept C207001950 @default.
- W2002045669 hasConcept C2777025900 @default.
- W2002045669 hasConcept C2778646069 @default.
- W2002045669 hasConcept C2779133491 @default.
- W2002045669 hasConcept C2780394083 @default.
- W2002045669 hasConcept C2780886150 @default.
- W2002045669 hasConcept C503630168 @default.
- W2002045669 hasConcept C51738704 @default.
- W2002045669 hasConcept C71924100 @default.
- W2002045669 hasConcept C86803240 @default.
- W2002045669 hasConceptScore W2002045669C105702510 @default.
- W2002045669 hasConceptScore W2002045669C113045295 @default.
- W2002045669 hasConceptScore W2002045669C126322002 @default.
- W2002045669 hasConceptScore W2002045669C134018914 @default.
- W2002045669 hasConceptScore W2002045669C142724271 @default.
- W2002045669 hasConceptScore W2002045669C150903083 @default.
- W2002045669 hasConceptScore W2002045669C167734588 @default.
- W2002045669 hasConceptScore W2002045669C207001950 @default.
- W2002045669 hasConceptScore W2002045669C2777025900 @default.
- W2002045669 hasConceptScore W2002045669C2778646069 @default.
- W2002045669 hasConceptScore W2002045669C2779133491 @default.
- W2002045669 hasConceptScore W2002045669C2780394083 @default.
- W2002045669 hasConceptScore W2002045669C2780886150 @default.
- W2002045669 hasConceptScore W2002045669C503630168 @default.
- W2002045669 hasConceptScore W2002045669C51738704 @default.
- W2002045669 hasConceptScore W2002045669C71924100 @default.
- W2002045669 hasConceptScore W2002045669C86803240 @default.
- W2002045669 hasIssue "2" @default.
- W2002045669 hasLocation W20020456691 @default.
- W2002045669 hasLocation W20020456692 @default.
- W2002045669 hasOpenAccess W2002045669 @default.
- W2002045669 hasPrimaryLocation W20020456691 @default.
- W2002045669 hasRelatedWork W1974265403 @default.
- W2002045669 hasRelatedWork W1987704889 @default.
- W2002045669 hasRelatedWork W2065390408 @default.
- W2002045669 hasRelatedWork W2073932624 @default.
- W2002045669 hasRelatedWork W2079305414 @default.
- W2002045669 hasRelatedWork W2222932910 @default.
- W2002045669 hasRelatedWork W2273020534 @default.
- W2002045669 hasRelatedWork W2312572943 @default.
- W2002045669 hasRelatedWork W2619321739 @default.
- W2002045669 hasRelatedWork W3095683718 @default.
- W2002045669 hasVolume "118" @default.
- W2002045669 isParatext "false" @default.
- W2002045669 isRetracted "false" @default.
- W2002045669 magId "2002045669" @default.
- W2002045669 workType "article" @default.