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• W2002047536 abstract "Abstract We attempt quantitative implementation of a previous suggestion that asymmetric charge neutralization of DNA phosphate groups may provide part of the driving force for nucleosome folding. Polyelectrolyte theory can be used to estimate the effective compressive force acting along the length of one side of the DNA surface when a fraction of the phosphate groups are neutralized by histones bound to that side. A standard engineering formula then relates the force to the bending amplitude caused by it. Calculated bending amplitudes are consistent with the curvature of nucleosomal DNA and the overall extent of charge neutralization by the histones. The relation of the model to various aspects of nucleosome folding, including the detailed path of core-particle DNA is discussed. Several other DNA-protein complexes are listed as examples of possible asymmetric charge-induced bending." @default.
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• W2002047536 date "1989-04-01" @default.
• W2002047536 modified "2023-10-16" @default.
• W2002047536 title "An Estimate of the Extent of Folding of Nucleosomal DNA by Laterally Asymmetric Neutralization of Phosphate Groups" @default.
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• W2002047536 doi "https://doi.org/10.1080/07391102.1989.10506519" @default.
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