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- W2002048868 abstract "Chitin synthase converts uridine diphosphoryl-N-acetylglucosamine (UDP-GlcNAc) to chitin (poly-beta-(1-->4)-GlcNAc). During polymerization, elongation occurs at the 4-OH (nonreducing) terminus of the growing chitin chain. Blockage of the 4-OH via incorporation of UDP-N-acetyl-4-O-methylglucosamine (UDP-4-OMe-GlcNAc, 3) can potentially terminate chitin polymerization, and represents a novel strategy for chitin synthase inhibition. The chemical synthesis of 3 and preliminary evaluation of its possible incorporation by chitin synthase are reported herein." @default.
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- W2002048868 date "2004-06-01" @default.
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- W2002048868 title "Chemical synthesis of UDP-4-O-methyl-GlcNAc, a potential chain terminator of chitin synthesis" @default.
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- W2002048868 doi "https://doi.org/10.1016/j.carres.2004.03.014" @default.
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