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- W2002049130 abstract "Natural IgM antibodies are typical victims of prejudices which originated in the mid 80 s. Over the years, these molecules were considered as the pariahs among the immune competent molecules and their characteristic properties, like low affinity, cross-reactivity and pentameric structure, were assessed as useless, difficult, nebulous, etc. Today, mainly based on a few scientists' persistent work and the key discoveries on innate immune recognition, natural IgM antibodies are “back on stage”. Their role in the immune response against bacteria, viruses, fungi and possibly modified self-components as well as in therapy and diagnosis of malignancies is accepted. All the so far negatively judged features are seen in a different light, e.g. low affinity seems to be good for function and does not exclude specificity, and cross-reactivity is no longer judged as unspecific, but instead as a very economic way of immune recognition. And at last, with the use of natural IgM antibodies, a new field of tumor-specific targets has been encountered, the carbo-neo-epitopes. Therefore, by having learned from nature, the renaissance of natural IgM antibodies opens a new area of cancer therapeutics and diagnostics." @default.
- W2002049130 created "2016-06-24" @default.
- W2002049130 creator A5060201982 @default.
- W2002049130 creator A5076169179 @default.
- W2002049130 date "2006-08-01" @default.
- W2002049130 modified "2023-09-29" @default.
- W2002049130 title "Natural IgM antibodies: The orphaned molecules in immune surveillance" @default.
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- W2002049130 cites W1483148939 @default.
- W2002049130 cites W1483194800 @default.
- W2002049130 cites W1489842152 @default.
- W2002049130 cites W1494595774 @default.
- W2002049130 cites W1528800735 @default.
- W2002049130 cites W1538906753 @default.
- W2002049130 cites W1624366049 @default.
- W2002049130 cites W169978917 @default.
- W2002049130 cites W1735540178 @default.
- W2002049130 cites W1786423522 @default.
- W2002049130 cites W1787255496 @default.
- W2002049130 cites W1874138552 @default.
- W2002049130 cites W1919334117 @default.
- W2002049130 cites W1948067800 @default.
- W2002049130 cites W1966337146 @default.
- W2002049130 cites W1967197631 @default.
- W2002049130 cites W1974489930 @default.
- W2002049130 cites W1983121280 @default.
- W2002049130 cites W1983902425 @default.
- W2002049130 cites W1985766571 @default.
- W2002049130 cites W1987640672 @default.
- W2002049130 cites W1990362461 @default.
- W2002049130 cites W1992691983 @default.
- W2002049130 cites W1995938018 @default.
- W2002049130 cites W2003052374 @default.
- W2002049130 cites W2004054985 @default.
- W2002049130 cites W2004773897 @default.
- W2002049130 cites W2006840853 @default.
- W2002049130 cites W2016761322 @default.
- W2002049130 cites W2020082741 @default.
- W2002049130 cites W2023625270 @default.
- W2002049130 cites W2030572845 @default.
- W2002049130 cites W2033699650 @default.
- W2002049130 cites W2034515222 @default.
- W2002049130 cites W2034521338 @default.
- W2002049130 cites W2036089963 @default.
- W2002049130 cites W2038525648 @default.
- W2002049130 cites W2041912408 @default.
- W2002049130 cites W2044098624 @default.
- W2002049130 cites W2045232776 @default.
- W2002049130 cites W2046972425 @default.
- W2002049130 cites W2047433262 @default.
- W2002049130 cites W2048936294 @default.
- W2002049130 cites W2053186573 @default.
- W2002049130 cites W2057618822 @default.
- W2002049130 cites W2061044161 @default.
- W2002049130 cites W2061718399 @default.
- W2002049130 cites W2063123838 @default.
- W2002049130 cites W2064520407 @default.
- W2002049130 cites W2066765839 @default.
- W2002049130 cites W2069451410 @default.
- W2002049130 cites W2073211520 @default.
- W2002049130 cites W2081579806 @default.
- W2002049130 cites W2083260383 @default.
- W2002049130 cites W2084312859 @default.
- W2002049130 cites W2084730306 @default.
- W2002049130 cites W2086013987 @default.
- W2002049130 cites W2090640877 @default.
- W2002049130 cites W2094682437 @default.
- W2002049130 cites W2097747132 @default.
- W2002049130 cites W2100025269 @default.
- W2002049130 cites W2109924462 @default.
- W2002049130 cites W2111869415 @default.
- W2002049130 cites W2114737175 @default.
- W2002049130 cites W2126012511 @default.
- W2002049130 cites W2132566631 @default.
- W2002049130 cites W2133449490 @default.
- W2002049130 cites W2139968053 @default.
- W2002049130 cites W2146651191 @default.
- W2002049130 cites W2157042020 @default.
- W2002049130 cites W2159490575 @default.
- W2002049130 cites W2165804863 @default.
- W2002049130 cites W2170227084 @default.
- W2002049130 cites W2175262016 @default.
- W2002049130 cites W2413873230 @default.
- W2002049130 cites W2464061827 @default.
- W2002049130 doi "https://doi.org/10.1016/j.addr.2005.08.007" @default.
- W2002049130 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16820243" @default.
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