Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002049916> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2002049916 endingPage "40" @default.
- W2002049916 startingPage "35" @default.
- W2002049916 abstract "Previous studies in this laboratory have implicated the membrane transport protein Na/K/Cl cotransporter (NKCC1) as an important component of the signaling pathways activated by phorbol esters in BALB/c 3T3 cells. The NKCC1 protein functions as a Na/K/Cl cotransporter in BALB/c 3T3 cells and many other cell types. Loss of NKCC1 function has been associated with loss of mitogenic responsiveness to phorbol ester. Here we report that expression of a cloned NKCC1 cDNA fused to a tetracycline-regulated promoter in BALB/c 3T3 cells deficient in Na/K/Cl cotransport activity (clone E12a cells) restored cotransport function. Compared with parental cotransport-deficient cells, transfected clones expressing the exogenous NKCC1 gene responded like typical BALB/c 3T3 cells to 12-O-tetradecanoylphorbol-13-acetate: loop diuretic-sensitive B6Rb+ flux was inhibited, cell volume was decreased, and cell growth was stimulated. These results support our previous conclusion that the loss of responsiveness of E12a cells to phorbol ester is caused by mutation of the endogenous NKCC1 gene. © 1996 Wiley-Liss, Inc." @default.
- W2002049916 created "2016-06-24" @default.
- W2002049916 creator A5048937348 @default.
- W2002049916 creator A5073771007 @default.
- W2002049916 date "1996-09-01" @default.
- W2002049916 modified "2023-09-23" @default.
- W2002049916 title "Restoration of responsiveness to phorbol ester by reconstitution of a functional Na/K/Cl cotransporter in cotransporter-deficient BALB/c 3T3 cells" @default.
- W2002049916 cites W1964485689 @default.
- W2002049916 cites W1976462601 @default.
- W2002049916 cites W1983501834 @default.
- W2002049916 cites W1995940631 @default.
- W2002049916 cites W2001399809 @default.
- W2002049916 cites W2019911238 @default.
- W2002049916 cites W2035172727 @default.
- W2002049916 cites W2038087154 @default.
- W2002049916 cites W2043815378 @default.
- W2002049916 cites W2049082430 @default.
- W2002049916 cites W2051942713 @default.
- W2002049916 cites W2073221020 @default.
- W2002049916 cites W2089475281 @default.
- W2002049916 cites W2090429649 @default.
- W2002049916 cites W2134263027 @default.
- W2002049916 cites W2159359588 @default.
- W2002049916 cites W2188196872 @default.
- W2002049916 doi "https://doi.org/10.1002/(sici)1098-2744(199609)17:1<35::aid-mc5>3.0.co;2-j" @default.
- W2002049916 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8876673" @default.
- W2002049916 hasPublicationYear "1996" @default.
- W2002049916 type Work @default.
- W2002049916 sameAs 2002049916 @default.
- W2002049916 citedByCount "2" @default.
- W2002049916 crossrefType "journal-article" @default.
- W2002049916 hasAuthorship W2002049916A5048937348 @default.
- W2002049916 hasAuthorship W2002049916A5073771007 @default.
- W2002049916 hasConcept C104317684 @default.
- W2002049916 hasConcept C120405084 @default.
- W2002049916 hasConcept C149011108 @default.
- W2002049916 hasConcept C153911025 @default.
- W2002049916 hasConcept C178790620 @default.
- W2002049916 hasConcept C185592680 @default.
- W2002049916 hasConcept C188053792 @default.
- W2002049916 hasConcept C195794163 @default.
- W2002049916 hasConcept C2776746612 @default.
- W2002049916 hasConcept C2780043322 @default.
- W2002049916 hasConcept C537181965 @default.
- W2002049916 hasConcept C54009773 @default.
- W2002049916 hasConcept C54355233 @default.
- W2002049916 hasConcept C55493867 @default.
- W2002049916 hasConcept C62478195 @default.
- W2002049916 hasConcept C81885089 @default.
- W2002049916 hasConcept C86803240 @default.
- W2002049916 hasConceptScore W2002049916C104317684 @default.
- W2002049916 hasConceptScore W2002049916C120405084 @default.
- W2002049916 hasConceptScore W2002049916C149011108 @default.
- W2002049916 hasConceptScore W2002049916C153911025 @default.
- W2002049916 hasConceptScore W2002049916C178790620 @default.
- W2002049916 hasConceptScore W2002049916C185592680 @default.
- W2002049916 hasConceptScore W2002049916C188053792 @default.
- W2002049916 hasConceptScore W2002049916C195794163 @default.
- W2002049916 hasConceptScore W2002049916C2776746612 @default.
- W2002049916 hasConceptScore W2002049916C2780043322 @default.
- W2002049916 hasConceptScore W2002049916C537181965 @default.
- W2002049916 hasConceptScore W2002049916C54009773 @default.
- W2002049916 hasConceptScore W2002049916C54355233 @default.
- W2002049916 hasConceptScore W2002049916C55493867 @default.
- W2002049916 hasConceptScore W2002049916C62478195 @default.
- W2002049916 hasConceptScore W2002049916C81885089 @default.
- W2002049916 hasConceptScore W2002049916C86803240 @default.
- W2002049916 hasIssue "1" @default.
- W2002049916 hasLocation W20020499161 @default.
- W2002049916 hasLocation W20020499162 @default.
- W2002049916 hasOpenAccess W2002049916 @default.
- W2002049916 hasPrimaryLocation W20020499161 @default.
- W2002049916 hasRelatedWork W1975455000 @default.
- W2002049916 hasRelatedWork W2002049916 @default.
- W2002049916 hasRelatedWork W2013829613 @default.
- W2002049916 hasRelatedWork W2025028661 @default.
- W2002049916 hasRelatedWork W2049082430 @default.
- W2002049916 hasRelatedWork W2081583095 @default.
- W2002049916 hasRelatedWork W2159359588 @default.
- W2002049916 hasRelatedWork W2408959994 @default.
- W2002049916 hasRelatedWork W2418676040 @default.
- W2002049916 hasRelatedWork W2464035826 @default.
- W2002049916 hasVolume "17" @default.
- W2002049916 isParatext "false" @default.
- W2002049916 isRetracted "false" @default.
- W2002049916 magId "2002049916" @default.
- W2002049916 workType "article" @default.