Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002054902> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W2002054902 endingPage "86" @default.
- W2002054902 startingPage "78" @default.
- W2002054902 abstract "Sex differences are reported for methamphetamine (MA)-induced neurotoxicity of the nigrostriatal dopaminergic system. In an attempt to understand some of the bases for these differences, we investigated MA-evoked dopamine (DA) responses from superfused striatal tissue fragments of intact and male and female CD-1 mice. These responses were compared with that of gonadectomized mice, potassium-evoked DA responses in intact mice and responses in prepubertal mice. In experiment 1, DA responses were tested using infusion of MA at doses of 1, 10, 100 and 1,000 microM. In intact mice, mean peak MA-evoked DA responses were consistently increased and significantly greater in male vs. female mice at the 1,000 microM dose. No such significant differences were observed between gonadectomized male vs. female mice (experiment 2). In contrast to MA, potassium-stimulated DA responses were increased in intact female mice, with statistically significant differences at doses of 30 and 60 mM (experiment 3). No statistically significant differences between intact prepubertal male and female mice were obtained in response to a 1,000 microM dose of MA (experiment 4) or to a 60 mM dose of potassium (experiment 5). These results indicate that intact male mice show greater sensitivity to MA-evoked DA output. This sex difference is abolished following gonadectomy, is not observed with potassium, nor is it present in prepubertal mice. The increased sensitivity to MA shown by intact males may be related to the greater degree of striatal dopaminergic neurotoxicity observed in male mice in response to this psychostimulant and appears to be attributable to differences in gonadal steroid hormones between male and female mice." @default.
- W2002054902 created "2016-06-24" @default.
- W2002054902 creator A5002935731 @default.
- W2002054902 creator A5029887779 @default.
- W2002054902 date "2005-01-01" @default.
- W2002054902 modified "2023-09-23" @default.
- W2002054902 title "Sex Differences in Methamphetamine-Evoked Striatal Dopamine Output Are Abolished following Gonadectomy: Comparisons with Potassium-Evoked Output and Responses in Prepubertal Mice" @default.
- W2002054902 cites W2004263583 @default.
- W2002054902 cites W2005763938 @default.
- W2002054902 cites W2152378366 @default.
- W2002054902 doi "https://doi.org/10.1159/000090983" @default.
- W2002054902 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16415598" @default.
- W2002054902 hasPublicationYear "2005" @default.
- W2002054902 type Work @default.
- W2002054902 sameAs 2002054902 @default.
- W2002054902 citedByCount "21" @default.
- W2002054902 countsByYear W20020549022012 @default.
- W2002054902 countsByYear W20020549022013 @default.
- W2002054902 countsByYear W20020549022014 @default.
- W2002054902 countsByYear W20020549022016 @default.
- W2002054902 countsByYear W20020549022020 @default.
- W2002054902 crossrefType "journal-article" @default.
- W2002054902 hasAuthorship W2002054902A5002935731 @default.
- W2002054902 hasAuthorship W2002054902A5029887779 @default.
- W2002054902 hasConcept C126322002 @default.
- W2002054902 hasConcept C134018914 @default.
- W2002054902 hasConcept C137183658 @default.
- W2002054902 hasConcept C185592680 @default.
- W2002054902 hasConcept C2780376393 @default.
- W2002054902 hasConcept C513476851 @default.
- W2002054902 hasConcept C71924100 @default.
- W2002054902 hasConcept C86803240 @default.
- W2002054902 hasConceptScore W2002054902C126322002 @default.
- W2002054902 hasConceptScore W2002054902C134018914 @default.
- W2002054902 hasConceptScore W2002054902C137183658 @default.
- W2002054902 hasConceptScore W2002054902C185592680 @default.
- W2002054902 hasConceptScore W2002054902C2780376393 @default.
- W2002054902 hasConceptScore W2002054902C513476851 @default.
- W2002054902 hasConceptScore W2002054902C71924100 @default.
- W2002054902 hasConceptScore W2002054902C86803240 @default.
- W2002054902 hasIssue "2" @default.
- W2002054902 hasLocation W20020549021 @default.
- W2002054902 hasLocation W20020549022 @default.
- W2002054902 hasOpenAccess W2002054902 @default.
- W2002054902 hasPrimaryLocation W20020549021 @default.
- W2002054902 hasRelatedWork W1963640353 @default.
- W2002054902 hasRelatedWork W1979059193 @default.
- W2002054902 hasRelatedWork W1983836497 @default.
- W2002054902 hasRelatedWork W2015327999 @default.
- W2002054902 hasRelatedWork W2034255477 @default.
- W2002054902 hasRelatedWork W2062579683 @default.
- W2002054902 hasRelatedWork W2064918881 @default.
- W2002054902 hasRelatedWork W2080277814 @default.
- W2002054902 hasRelatedWork W2163744984 @default.
- W2002054902 hasRelatedWork W2171851218 @default.
- W2002054902 hasVolume "82" @default.
- W2002054902 isParatext "false" @default.
- W2002054902 isRetracted "false" @default.
- W2002054902 magId "2002054902" @default.
- W2002054902 workType "article" @default.