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- W2002062009 abstract "To elucidate T(4) metabolism in various cell types of rat retina, 5-monodeiodinating and 5?-monodeiodinating activities were studied in retinal cell layers obtained by selective cytotoxic action of monosodium glutamate on bipolar and ganglion cell layers and by iodoacetate effect on photoreceptor cells. Concomitantly these enzyme activities were studied in C3H/HeN mouse retina genetically deprived of photoreceptor cells. Deiodinase activities were low in rat and mouse retina deprived of photoreceptors. The 5?-monodeiodination rate of T(4) was higher than T(4) tyrosyl ring deiodination in cell layers examined and the highest values were found in the photoreceptor cells. Data support the hypothesis that phenolic and tyrosyl ring deiodinase activities are present in the photoreceptor cells. Their reciprocal changes may regulate the nuclear function which in turn controls the rhythmical renewal of rod outer segments." @default.
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- W2002062009 date "1985-01-01" @default.
- W2002062009 modified "2023-09-27" @default.
- W2002062009 title "The localization of phenolic and tyrosyl ring thyroxine deiodination in rat and mouse retina" @default.
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- W2002062009 doi "https://doi.org/10.1016/0197-0186(85)90150-0" @default.
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