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- W2002065197 endingPage "225" @default.
- W2002065197 startingPage "209" @default.
- W2002065197 abstract "Glycoconjugates are utilized by eukaryotic organisms ranging from yeast to humans for the cell surface expression of a wide variety of proteins and lipids. These glycoconjugates are expressed as enzymes or receptors and serve a diversity of functions, including cell signaling and cell survival. In parasitic protozoans, glycoconjugates play roles in infectivity, survival, virulence and immune evasion. Among the alternate glycoconjugate structures that have been identified, glycosylphosphatidylinositols (GPIs) represent a universal structure for the anchorage of proteins, lipids, and phosphosaccharides to cellular membranes. Biosynthesis of the GPI is a multi-step process that culminates in the attachment of the assembled GPI to a precursor protein. This final step in the transfer of the GPI to a protein is catalyzed by GPI8 of the putative transamidase complex (TAM). GPI8 functions dually to perform the proteolytic cleavage of the C-terminal signal sequence of the precursor protein, followed by the formation of an amide bond between the protein and the ethanolamine phosphate of the GPI. This review summarizes the current aggregate of biochemical, gene-disruption and active site mutagenesis studies, which provide evidence that GPI8 is responsible for the protein-GPI anchoring reaction. We describe recently published studies that have identified other potential components of the TAM complex and that have elucidated their likely role in protein-GPI attachment. Further, we discuss the biochemical, molecular and functional differences between protozoan and mammalian GPI8 and the protein-GPI anchoring machinery. Finally, we will present the implications of these studies for the development of anti-parasite drug therapies." @default.
- W2002065197 created "2016-06-24" @default.
- W2002065197 creator A5046311190 @default.
- W2002065197 creator A5065183058 @default.
- W2002065197 date "2006-01-01" @default.
- W2002065197 modified "2023-10-16" @default.
- W2002065197 title "Recent developments in the molecular, biochemical and functional characterization of GPI8 and the GPI-anchoring mechanism [Review]" @default.
- W2002065197 cites W1487665505 @default.
- W2002065197 cites W1503075447 @default.
- W2002065197 cites W1524475863 @default.
- W2002065197 cites W1551725031 @default.
- W2002065197 cites W1552234210 @default.
- W2002065197 cites W1555403344 @default.
- W2002065197 cites W1567843024 @default.
- W2002065197 cites W1574519829 @default.
- W2002065197 cites W1577534043 @default.
- W2002065197 cites W1600346161 @default.
- W2002065197 cites W1613123331 @default.
- W2002065197 cites W1626163495 @default.
- W2002065197 cites W16534552 @default.
- W2002065197 cites W1680217275 @default.
- W2002065197 cites W1683957338 @default.
- W2002065197 cites W168609892 @default.
- W2002065197 cites W1739092746 @default.
- W2002065197 cites W1747904750 @default.
- W2002065197 cites W1818042852 @default.
- W2002065197 cites W1820925498 @default.
- W2002065197 cites W1867790876 @default.
- W2002065197 cites W1915912984 @default.
- W2002065197 cites W1944304173 @default.
- W2002065197 cites W1960975851 @default.
- W2002065197 cites W1964728393 @default.
- W2002065197 cites W1968292510 @default.
- W2002065197 cites W1970413776 @default.
- W2002065197 cites W1972332110 @default.
- W2002065197 cites W1973030143 @default.
- W2002065197 cites W1973493491 @default.
- W2002065197 cites W1975505603 @default.
- W2002065197 cites W1979620684 @default.
- W2002065197 cites W1980969503 @default.
- W2002065197 cites W1985619086 @default.
- W2002065197 cites W1986111653 @default.
- W2002065197 cites W1987935025 @default.
- W2002065197 cites W1992826790 @default.
- W2002065197 cites W1993527188 @default.
- W2002065197 cites W1995709387 @default.
- W2002065197 cites W1997768741 @default.
- W2002065197 cites W2002764122 @default.
- W2002065197 cites W2002994480 @default.
- W2002065197 cites W2003299938 @default.
- W2002065197 cites W2004709114 @default.
- W2002065197 cites W2009475049 @default.
- W2002065197 cites W2014981059 @default.
- W2002065197 cites W2021707965 @default.
- W2002065197 cites W2022204091 @default.
- W2002065197 cites W2023359733 @default.
- W2002065197 cites W2025731044 @default.
- W2002065197 cites W2028630606 @default.
- W2002065197 cites W2030701944 @default.
- W2002065197 cites W2031045991 @default.
- W2002065197 cites W2038736974 @default.
- W2002065197 cites W2039070421 @default.
- W2002065197 cites W2039217586 @default.
- W2002065197 cites W2041257080 @default.
- W2002065197 cites W2041909095 @default.
- W2002065197 cites W2041991446 @default.
- W2002065197 cites W2042291896 @default.
- W2002065197 cites W2044163799 @default.
- W2002065197 cites W2044215638 @default.
- W2002065197 cites W2044908214 @default.
- W2002065197 cites W2047630725 @default.
- W2002065197 cites W2051722675 @default.
- W2002065197 cites W2053255035 @default.
- W2002065197 cites W2053396821 @default.
- W2002065197 cites W2065681923 @default.
- W2002065197 cites W2067171199 @default.
- W2002065197 cites W2070427922 @default.
- W2002065197 cites W2070447989 @default.
- W2002065197 cites W2072186058 @default.
- W2002065197 cites W2072633195 @default.
- W2002065197 cites W2076462275 @default.
- W2002065197 cites W2077860019 @default.
- W2002065197 cites W2079188087 @default.
- W2002065197 cites W2080429285 @default.
- W2002065197 cites W2082161587 @default.
- W2002065197 cites W2082557203 @default.
- W2002065197 cites W2087677809 @default.
- W2002065197 cites W2091879499 @default.
- W2002065197 cites W2100285359 @default.
- W2002065197 cites W2100671800 @default.
- W2002065197 cites W2101704513 @default.
- W2002065197 cites W2102182903 @default.
- W2002065197 cites W2103391080 @default.
- W2002065197 cites W2107752085 @default.
- W2002065197 cites W2110505696 @default.
- W2002065197 cites W2111565312 @default.
- W2002065197 cites W2114388625 @default.
- W2002065197 cites W2119343209 @default.