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• W2002067384 startingPage "1081" @default.
• W2002067384 abstract "Suction blister roofs taken from the involved and uninvolved epidermis of patients with vitiligo showed a consistent reduction in levels of catalase compared to normal healthy controls of matched photo-skin types (Fitzpatrick classification). A decrease in catalase activity is expected to increase the concentration of hydrogen peroxide in the epidermis of these patients. Hydrogen peroxide functions as a reversible inhibitor of human tyrosinase with a KI of 8 X 10(-6) M. Also, hydrogen peroxide undergoes photochemical reduction yielding highly reactive hydroxyl radicals (OH.) and hydroxyl ions (OH-) mainly by the Haber-Weiss reaction. Hydroxyl radicals are capable of bleaching constitutional melanin and cause membrane lysis through lipid peroxidation reactions. Hydroxyl ions increase the pH in the epidermis, and as a consequence glutathione reductase activity is increased in patients with vitiligo compared to controls. Based on these new results, together with the previously reported calcium transport defect, a new hypothesis has been formulated for the pathogenesis of vitiligo." @default.
• W2002067384 created "2016-06-24" @default.
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• W2002067384 date "1991-12-01" @default.
• W2002067384 modified "2023-10-17" @default.
• W2002067384 title "Low Catalase Levels in the Epidermis of Patients with Vitiligo" @default.
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• W2002067384 doi "https://doi.org/10.1111/1523-1747.ep12492612" @default.
• W2002067384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1748819" @default.
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