Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002067498> ?p ?o ?g. }
- W2002067498 endingPage "2604" @default.
- W2002067498 startingPage "2589" @default.
- W2002067498 abstract "Contemporary drug discovery leverages quantitative modeling and simulation with increasing emphasis, both to gain deeper knowledge of drug targets and mechanisms as well as improve predictions between preclinical models and clinical applications, such as first-in-human dose projections. Proliferation of novel biotherapeutic modalities increases the need for applied PK/PD modeling as a quantitative tool to advance new therapies. Of particular relevance is the understanding of exposure, target binding and associated pharmacology at the target site of interest. Bioanalytical methods are key to informing PK/PD models and require assessment of both PK and PD end points. Where targets are sequestered in tissues (noncirculating), the ability to quantitatively measure drug or biomarker in tissue compartments becomes particularly important. This perspective provides an overview of contemporary applications of quantitative bioanalysis in tissue compartments as applied to PK and PD assessments associated with novel biotherapeutics. Case studies and key references are provided." @default.
- W2002067498 created "2016-06-24" @default.
- W2002067498 creator A5005706542 @default.
- W2002067498 creator A5005718159 @default.
- W2002067498 creator A5010022627 @default.
- W2002067498 creator A5010249896 @default.
- W2002067498 creator A5011064270 @default.
- W2002067498 creator A5020133148 @default.
- W2002067498 creator A5022043445 @default.
- W2002067498 creator A5022553469 @default.
- W2002067498 creator A5030577283 @default.
- W2002067498 creator A5037475057 @default.
- W2002067498 creator A5041756626 @default.
- W2002067498 creator A5049499750 @default.
- W2002067498 creator A5064412429 @default.
- W2002067498 creator A5069522797 @default.
- W2002067498 creator A5078732483 @default.
- W2002067498 creator A5079892593 @default.
- W2002067498 creator A5085131390 @default.
- W2002067498 date "2012-11-01" @default.
- W2002067498 modified "2023-10-07" @default.
- W2002067498 title "Tissue bioanalysis of biotherapeutics and drug targets to support PK/PD" @default.
- W2002067498 cites W1552788610 @default.
- W2002067498 cites W1602921644 @default.
- W2002067498 cites W171120803 @default.
- W2002067498 cites W1892570697 @default.
- W2002067498 cites W1964083777 @default.
- W2002067498 cites W1965298106 @default.
- W2002067498 cites W1967187739 @default.
- W2002067498 cites W1973587651 @default.
- W2002067498 cites W1986016424 @default.
- W2002067498 cites W1986852088 @default.
- W2002067498 cites W1988166395 @default.
- W2002067498 cites W1989730293 @default.
- W2002067498 cites W1994570353 @default.
- W2002067498 cites W1996998905 @default.
- W2002067498 cites W2002765161 @default.
- W2002067498 cites W2003039907 @default.
- W2002067498 cites W2008751117 @default.
- W2002067498 cites W2014921813 @default.
- W2002067498 cites W2016094048 @default.
- W2002067498 cites W2017449311 @default.
- W2002067498 cites W2018418352 @default.
- W2002067498 cites W2019137678 @default.
- W2002067498 cites W2020881594 @default.
- W2002067498 cites W2036914011 @default.
- W2002067498 cites W2037356096 @default.
- W2002067498 cites W2047468566 @default.
- W2002067498 cites W2048226370 @default.
- W2002067498 cites W2050080951 @default.
- W2002067498 cites W2056079638 @default.
- W2002067498 cites W2056405796 @default.
- W2002067498 cites W2056439160 @default.
- W2002067498 cites W2059347459 @default.
- W2002067498 cites W2061760261 @default.
- W2002067498 cites W2062826169 @default.
- W2002067498 cites W2065287796 @default.
- W2002067498 cites W2068481474 @default.
- W2002067498 cites W2072011053 @default.
- W2002067498 cites W2072292604 @default.
- W2002067498 cites W2074150933 @default.
- W2002067498 cites W2075840740 @default.
- W2002067498 cites W2077766071 @default.
- W2002067498 cites W2080335269 @default.
- W2002067498 cites W2084564836 @default.
- W2002067498 cites W2091929661 @default.
- W2002067498 cites W2094595413 @default.
- W2002067498 cites W2108355984 @default.
- W2002067498 cites W2110903116 @default.
- W2002067498 cites W2112154408 @default.
- W2002067498 cites W2112204146 @default.
- W2002067498 cites W2112513512 @default.
- W2002067498 cites W2113916926 @default.
- W2002067498 cites W2115292116 @default.
- W2002067498 cites W2116150122 @default.
- W2002067498 cites W2117287075 @default.
- W2002067498 cites W2121404525 @default.
- W2002067498 cites W2129937834 @default.
- W2002067498 cites W2130077384 @default.
- W2002067498 cites W2133413107 @default.
- W2002067498 cites W2138352319 @default.
- W2002067498 cites W2141105945 @default.
- W2002067498 cites W2152792405 @default.
- W2002067498 cites W2157721033 @default.
- W2002067498 cites W2166440745 @default.
- W2002067498 cites W4239003969 @default.
- W2002067498 cites W4251921694 @default.
- W2002067498 cites W2054144220 @default.
- W2002067498 doi "https://doi.org/10.4155/bio.12.234" @default.
- W2002067498 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23173794" @default.
- W2002067498 hasPublicationYear "2012" @default.
- W2002067498 type Work @default.
- W2002067498 sameAs 2002067498 @default.
- W2002067498 citedByCount "33" @default.
- W2002067498 countsByYear W20020674982013 @default.
- W2002067498 countsByYear W20020674982014 @default.
- W2002067498 countsByYear W20020674982016 @default.
- W2002067498 countsByYear W20020674982017 @default.