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- W2002067820 abstract "Investigative and therapeutic approaches to cardiogenic shock in acute myocardial infarction have been dominated by hemodynamic considerations. Cardiac output, arterial blood pressure, vasomotor tone, and organ perfusion have been the prime concern of researcher and clinician. Humoral factors, generally related to the sympathetic-adrenergic system, assumed importance only insofar as they influenced the hemodynamics of the circulation. Currently, the focus is shifting to humoral factors as they affect biochemical processes at the cellular level. Several have been shown recently to play an important part in various forms of shock. Most prominent in<i>cardiogenic</i>shock is the<i>myocardial depressant factor</i>(MDF), a small peptide of molecular weight range between 800 and 1,000 discovered in 1966 by Brand and Lefer.<sup>1</sup> Formation of MDF is initiated by vasoconstriction in the splanchnic vascular bed in response to a fall in systemic arterial blood pressure. This commendable homeostatic attempt to shunt blood to vital organs" @default.
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- W2002067820 date "1974-04-22" @default.
- W2002067820 modified "2023-10-14" @default.
- W2002067820 title "Myocardial Depressant Factor (MDF) in Cardiogenic Shock" @default.
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- W2002067820 doi "https://doi.org/10.1001/jama.1974.03230290048035" @default.
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