FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002068990> ?p ?o ?g. }

• W2002068990 endingPage "17726" @default.
• W2002068990 startingPage "17721" @default.
• W2002068990 abstract "Expression of herpes simplex virus genes at the initiation of replication involves two steps that take place at ND10 nuclear bodies. These are suppression of cellular repressors that attempt to silence viral DNA and remodeling of the viral chromatin to make it accessible for transcription. In earlier studies we reported on the mechanism by which viral proteins ICP0 and U(S)3 protein kinase modify and disrupt the HDAC1/CoREST/REST/LSD1 repressor complex. The remodeling step requires in addition acetylation of histones bound to DNA. In an attempt to identify the enzyme, we took note of the observation that ICP0 physically and functionally interacts with Bmal1, a partner of the CLOCK histone acetyl transferase, and key members of the bHLH-PAS family of transcriptional factors. The Bmal11 and CLOCK heterodimer is best known as a regulator of the circadian oscillation in the mammalian CLOCK system. In this article we report the following: (i) in infected cells both Bmal1 and CLOCK localize at ND10 bodies; (ii) wild-type virus stabilizes the CLOCK protein; (iii) overexpression of CLOCK partially compensates for the absence of ICP0 and enables higher yields in cells infected with a ΔICP0 mutant and this activity is not expressed by CLOCK mutants lacking histone acetyl transferase activity; and (iv) depletion of CLOCK in cells infected with wild-type virus results in significant decrease in the expression of all viral proteins tested. We conclude that ICP0 interacts with Bmal1 and by extension with CLOCK histone acetyl transferase to remodel viral chromatin." @default.
• W2002068990 created "2016-06-24" @default.
• W2002068990 creator A5053720647 @default.
• W2002068990 creator A5063759652 @default.
• W2002068990 date "2010-09-27" @default.
• W2002068990 modified "2023-10-14" @default.
• W2002068990 title "Circadian CLOCK histone acetyl transferase localizes at ND10 nuclear bodies and enables herpes simplex virus gene expression" @default.
• W2002068990 cites W1516008369 @default.
• W2002068990 cites W1969883219 @default.
• W2002068990 cites W1970010476 @default.
• W2002068990 cites W1985110168 @default.
• W2002068990 cites W1989011389 @default.
• W2002068990 cites W2009132775 @default.
• W2002068990 cites W2015398239 @default.
• W2002068990 cites W2030981143 @default.
• W2002068990 cites W2035394208 @default.
• W2002068990 cites W2041640338 @default.
• W2002068990 cites W2044060792 @default.
• W2002068990 cites W2054513544 @default.
• W2002068990 cites W2060922355 @default.
• W2002068990 cites W2071198298 @default.
• W2002068990 cites W2073779028 @default.
• W2002068990 cites W2088348233 @default.
• W2002068990 cites W2097883984 @default.
• W2002068990 cites W2102232194 @default.
• W2002068990 cites W2113994143 @default.
• W2002068990 cites W2118584295 @default.
• W2002068990 cites W2125161768 @default.
• W2002068990 cites W2125833190 @default.
• W2002068990 cites W2134055860 @default.
• W2002068990 cites W2138630631 @default.
• W2002068990 cites W2143625239 @default.
• W2002068990 cites W2157454515 @default.
• W2002068990 cites W2167389860 @default.
• W2002068990 cites W4236019121 @default.
• W2002068990 doi "https://doi.org/10.1073/pnas.1012991107" @default.
• W2002068990 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2955081" @default.
• W2002068990 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20876123" @default.
• W2002068990 hasPublicationYear "2010" @default.
• W2002068990 type Work @default.
• W2002068990 sameAs 2002068990 @default.
• W2002068990 citedByCount "79" @default.
• W2002068990 countsByYear W20020689902012 @default.
• W2002068990 countsByYear W20020689902013 @default.
• W2002068990 countsByYear W20020689902014 @default.
• W2002068990 countsByYear W20020689902015 @default.
• W2002068990 countsByYear W20020689902016 @default.
• W2002068990 countsByYear W20020689902017 @default.
• W2002068990 countsByYear W20020689902018 @default.
• W2002068990 countsByYear W20020689902019 @default.
• W2002068990 countsByYear W20020689902020 @default.
• W2002068990 countsByYear W20020689902021 @default.
• W2002068990 countsByYear W20020689902022 @default.
• W2002068990 countsByYear W20020689902023 @default.
• W2002068990 crossrefType "journal-article" @default.
• W2002068990 hasAuthorship W2002068990A5053720647 @default.
• W2002068990 hasAuthorship W2002068990A5063759652 @default.
• W2002068990 hasBestOaLocation W20020689902 @default.
• W2002068990 hasConcept C104317684 @default.
• W2002068990 hasConcept C150425827 @default.
• W2002068990 hasConcept C153911025 @default.
• W2002068990 hasConcept C158448853 @default.
• W2002068990 hasConcept C38606739 @default.
• W2002068990 hasConcept C54355233 @default.
• W2002068990 hasConcept C64927066 @default.
• W2002068990 hasConcept C83640560 @default.
• W2002068990 hasConcept C86339819 @default.
• W2002068990 hasConcept C86803240 @default.
• W2002068990 hasConcept C95444343 @default.
• W2002068990 hasConceptScore W2002068990C104317684 @default.
• W2002068990 hasConceptScore W2002068990C150425827 @default.
• W2002068990 hasConceptScore W2002068990C153911025 @default.
• W2002068990 hasConceptScore W2002068990C158448853 @default.
• W2002068990 hasConceptScore W2002068990C38606739 @default.
• W2002068990 hasConceptScore W2002068990C54355233 @default.
• W2002068990 hasConceptScore W2002068990C64927066 @default.
• W2002068990 hasConceptScore W2002068990C83640560 @default.
• W2002068990 hasConceptScore W2002068990C86339819 @default.
• W2002068990 hasConceptScore W2002068990C86803240 @default.
• W2002068990 hasConceptScore W2002068990C95444343 @default.
• W2002068990 hasIssue "41" @default.
• W2002068990 hasLocation W20020689901 @default.
• W2002068990 hasLocation W20020689902 @default.
• W2002068990 hasLocation W20020689903 @default.
• W2002068990 hasLocation W20020689904 @default.
• W2002068990 hasOpenAccess W2002068990 @default.
• W2002068990 hasPrimaryLocation W20020689901 @default.
• W2002068990 hasRelatedWork W2010816189 @default.
• W2002068990 hasRelatedWork W2029798964 @default.
• W2002068990 hasRelatedWork W2030159793 @default.
• W2002068990 hasRelatedWork W2030814217 @default.
• W2002068990 hasRelatedWork W2049158685 @default.
• W2002068990 hasRelatedWork W2062280983 @default.
• W2002068990 hasRelatedWork W2076108054 @default.
• W2002068990 hasRelatedWork W2413824894 @default.
• W2002068990 hasRelatedWork W2790955376 @default.
• W2002068990 hasRelatedWork W98379584 @default.
• W2002068990 hasVolume "107" @default.

• next