FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002069346> ?p ?o ?g. }

• W2002069346 endingPage "170" @default.
• W2002069346 startingPage "165" @default.
• W2002069346 abstract "Recent evidence suggests that the lateral habenular complex (LHb) is a source of negative reward signals in midbrain dopaminergic neurons. LHb activity, in turn, is modulated by locally released dopamine, which is largely derived from the ventral tegmental area (VTA) via the mesohabenular pathway. Unfortunately, the presumed importance of this modulation has not been appreciated so far, as its intensity had been largely underestimated in previous reports. Consequently, the present study used contemporary techniques to reexamine the origin of dopaminergic fibers to the LHb. For this purpose, the retrograde tract-tracer gold-coupled wheatgerm agglutinin was injected into the LHb of fourteen rats. Four of these animals providing the most representative information were selected for detailed analysis. In total, 343 retrogradely labeled neurons were detected in the VTAs of these animals. By far most of them were found in the anterior VTA, accumulating in its ventral paramedian fields. About 47% (162) of retrogradely labeled cells displayed tyrosine hydroxylase immunoreactivity, suggesting that almost half of the mesohabenular neurons are dopaminergic. In addition, our data suggest that also incerto-hypothalamic and periventricular neurons contribute dopaminergic terminals to the LHb. The majority of LHb neurons, however, does not project to the origin of the mesohabenular pathway in the anterior VTA. Consequently, there might be no closed VTA-LHb-VTA loop. Instead, our data are in line with the idea that the anterior VTA via its projection to the medial part of the LHb may modulate the information flow from the limbic forebrain to monoaminergic midbrain nuclei." @default.
• W2002069346 created "2016-06-24" @default.
• W2002069346 creator A5009880402 @default.
• W2002069346 creator A5023569700 @default.
• W2002069346 creator A5050613504 @default.
• W2002069346 creator A5052394769 @default.
• W2002069346 creator A5079476204 @default.
• W2002069346 creator A5091662098 @default.
• W2002069346 date "2007-11-01" @default.
• W2002069346 modified "2023-10-01" @default.
• W2002069346 title "Dopaminergic projections from the VTA substantially contribute to the mesohabenular pathway in the rat" @default.
• W2002069346 cites W1542275754 @default.
• W2002069346 cites W1928473146 @default.
• W2002069346 cites W1953522602 @default.
• W2002069346 cites W1969480244 @default.
• W2002069346 cites W1983272530 @default.
• W2002069346 cites W1986446339 @default.
• W2002069346 cites W1994390109 @default.
• W2002069346 cites W1995176921 @default.
• W2002069346 cites W1995297474 @default.
• W2002069346 cites W1995506160 @default.
• W2002069346 cites W1997065612 @default.
• W2002069346 cites W2011482255 @default.
• W2002069346 cites W2014239075 @default.
• W2002069346 cites W2015455780 @default.
• W2002069346 cites W2017902760 @default.
• W2002069346 cites W2026129515 @default.
• W2002069346 cites W2026887008 @default.
• W2002069346 cites W2037457092 @default.
• W2002069346 cites W2042824612 @default.
• W2002069346 cites W2050599982 @default.
• W2002069346 cites W2051285144 @default.
• W2002069346 cites W2054920627 @default.
• W2002069346 cites W2065588777 @default.
• W2002069346 cites W2068949066 @default.
• W2002069346 cites W2081997259 @default.
• W2002069346 cites W2082720102 @default.
• W2002069346 cites W2090763917 @default.
• W2002069346 cites W2092206787 @default.
• W2002069346 cites W2105741420 @default.
• W2002069346 cites W2112594369 @default.
• W2002069346 cites W2121007598 @default.
• W2002069346 cites W2150561524 @default.
• W2002069346 cites W2161450513 @default.
• W2002069346 cites W2164509516 @default.
• W2002069346 cites W2179259141 @default.
• W2002069346 doi "https://doi.org/10.1016/j.neulet.2007.09.016" @default.
• W2002069346 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17949902" @default.
• W2002069346 hasPublicationYear "2007" @default.
• W2002069346 type Work @default.
• W2002069346 sameAs 2002069346 @default.
• W2002069346 citedByCount "72" @default.
• W2002069346 countsByYear W20020693462012 @default.
• W2002069346 countsByYear W20020693462013 @default.
• W2002069346 countsByYear W20020693462014 @default.
• W2002069346 countsByYear W20020693462015 @default.
• W2002069346 countsByYear W20020693462016 @default.
• W2002069346 countsByYear W20020693462017 @default.
• W2002069346 countsByYear W20020693462018 @default.
• W2002069346 countsByYear W20020693462019 @default.
• W2002069346 countsByYear W20020693462020 @default.
• W2002069346 countsByYear W20020693462021 @default.
• W2002069346 countsByYear W20020693462022 @default.
• W2002069346 countsByYear W20020693462023 @default.
• W2002069346 crossrefType "journal-article" @default.
• W2002069346 hasAuthorship W2002069346A5009880402 @default.
• W2002069346 hasAuthorship W2002069346A5023569700 @default.
• W2002069346 hasAuthorship W2002069346A5050613504 @default.
• W2002069346 hasAuthorship W2002069346A5052394769 @default.
• W2002069346 hasAuthorship W2002069346A5079476204 @default.
• W2002069346 hasAuthorship W2002069346A5091662098 @default.
• W2002069346 hasConcept C105702510 @default.
• W2002069346 hasConcept C137183658 @default.
• W2002069346 hasConcept C159167319 @default.
• W2002069346 hasConcept C169760540 @default.
• W2002069346 hasConcept C170493617 @default.
• W2002069346 hasConcept C2775864247 @default.
• W2002069346 hasConcept C2776286997 @default.
• W2002069346 hasConcept C2776669363 @default.
• W2002069346 hasConcept C2779715522 @default.
• W2002069346 hasConcept C2780948874 @default.
• W2002069346 hasConcept C42251903 @default.
• W2002069346 hasConcept C513476851 @default.
• W2002069346 hasConcept C529278444 @default.
• W2002069346 hasConcept C552161191 @default.
• W2002069346 hasConcept C55493867 @default.
• W2002069346 hasConcept C86803240 @default.
• W2002069346 hasConceptScore W2002069346C105702510 @default.
• W2002069346 hasConceptScore W2002069346C137183658 @default.
• W2002069346 hasConceptScore W2002069346C159167319 @default.
• W2002069346 hasConceptScore W2002069346C169760540 @default.
• W2002069346 hasConceptScore W2002069346C170493617 @default.
• W2002069346 hasConceptScore W2002069346C2775864247 @default.
• W2002069346 hasConceptScore W2002069346C2776286997 @default.
• W2002069346 hasConceptScore W2002069346C2776669363 @default.
• W2002069346 hasConceptScore W2002069346C2779715522 @default.
• W2002069346 hasConceptScore W2002069346C2780948874 @default.
• W2002069346 hasConceptScore W2002069346C42251903 @default.

• next