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• W2002070640 endingPage "2318" @default.
• W2002070640 startingPage "2318" @default.
• W2002070640 abstract "The (6–4) photoproduct is one of the major damaged bases produced by ultraviolet light in DNA. This lesion is known to be alkali-labile, and strand breaks occur at its sites when UV-irradiated DNA is treated with hot alkali. We have analyzed the product obtained by the alkali treatment of a dinucleoside monophosphate containing the (6–4) photoproduct, by HPLC, NMR spectroscopy, and mass spectrometry. We previously found that the N3–C4 bond of the 5′ component was hydrolyzed by a mild alkali treatment, and the present study revealed that the following reaction was the hydrolysis of the glycosidic bond at the 3′ component. The sugar moiety of this component was lost, even when a 3′-flanking nucleotide was not present. Glycosidic bond hydrolysis was also observed for a dimer and a trimer containing 5-methyl-2-pyrimidinone, which was used as an analog of the 3′ component of the (6–4) photoproduct, and its mechanism was elucidated. Finally, the alkali treatment of a tetramer, d(GT(6–4)TC), yielded 2′-deoxycytidine 5′-monophosphate, while 2′-deoxyguanosine 3′-monophosphate was not detected. This result demonstrated the hydrolysis of the glycosidic bond at the 3′ component of the (6–4) photoproduct and the subsequent strand break by β-elimination. It was also shown that the glycosidic bond at the 3′ component of the Dewar valence isomer was more alkali-labile than that of the (6–4) photoproduct." @default.
• W2002070640 created "2016-06-24" @default.
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• W2002070640 date "2012-01-01" @default.
• W2002070640 modified "2023-10-18" @default.
• W2002070640 title "Mechanism of the alkali degradation of (6–4) photoproduct-containing DNA" @default.
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• W2002070640 doi "https://doi.org/10.1039/c2ob06966k" @default.
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