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• W2002071731 abstract "Cisplatin ototoxicity has at least three major targets in the cochlea: the stria vascularis, the organ of Corti, and the spiral ganglion. This study aims to differentiate between these three targets. In particular, we address the question of whether the effects at the level of the organ of Corti and spiral ganglion are mutually dependent or whether they develop in parallel. This question was approached by studying the ototoxic effects while they develop electrophysiologically and comparing these to earlier presented histological data [Van Ruijven et al., 2004. Hear. Res. 197, 44-54]. Guinea pigs were treated with intraperitoneal injections of cisplatin at a dose of 2 mg/kg/day for either 4, 6, or 8 consecutive days. This time sequence has not revealed any evidence of one ototoxic process triggering another. Therefore, we have to stay with the conclusion of Van Ruijven et al. (2004) that both processes run in parallel." @default.
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• W2002071731 date "2005-07-01" @default.
• W2002071731 modified "2023-10-03" @default.
• W2002071731 title "The cochlear targets of cisplatin: An electrophysiological and morphological time-sequence study" @default.
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• W2002071731 doi "https://doi.org/10.1016/j.heares.2005.03.023" @default.
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