Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002072286> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2002072286 endingPage "110" @default.
- W2002072286 startingPage "87" @default.
- W2002072286 abstract "Regulation of T- and B-lymphocyte survival and death is crucial for maintaining immune homeostasis. Unresponsiveness to death signals can result in lymphoproliferative disorders including cancer and autoimmunity, whereas lymphocytes hypersensitive to such signals can be manifested as immunodeficiencies. Often within these cells, cytokines and their receptors regulate the critical balance between life and death. It is becoming ever more apparent that within these effector cascades, Janus tyrosine kinases (Jak) and signal transducers and activators of transcription (Stat) act as key regulatory components. Invaluable knowledge about Jaks and Stats has arisen from mice made genetically deficient in these molecules, tumor models, and proteomics/genomics, which has begun to define their role in survival versus apoptosis. These findings have also suggested how Jaks and Stats might be manipulated for therapeutic intervention in lymphoid-derived diseases. This review seeks to focus on the role of Jak tyrosine kinases and Stat transcription factors in mediating the lymphocyte life cycle." @default.
- W2002072286 created "2016-06-24" @default.
- W2002072286 creator A5027085103 @default.
- W2002072286 creator A5042453994 @default.
- W2002072286 creator A5051083446 @default.
- W2002072286 creator A5057862805 @default.
- W2002072286 creator A5087595506 @default.
- W2002072286 date "2004-01-01" @default.
- W2002072286 modified "2023-10-16" @default.
- W2002072286 title "Regulation of Lymphoid Cell Apoptosis by Jaks and Stats;" @default.
- W2002072286 doi "https://doi.org/10.1615/critrevimmunol.v24.i2.10" @default.
- W2002072286 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15581392" @default.
- W2002072286 hasPublicationYear "2004" @default.
- W2002072286 type Work @default.
- W2002072286 sameAs 2002072286 @default.
- W2002072286 citedByCount "9" @default.
- W2002072286 countsByYear W20020722862012 @default.
- W2002072286 countsByYear W20020722862013 @default.
- W2002072286 countsByYear W20020722862014 @default.
- W2002072286 crossrefType "journal-article" @default.
- W2002072286 hasAuthorship W2002072286A5027085103 @default.
- W2002072286 hasAuthorship W2002072286A5042453994 @default.
- W2002072286 hasAuthorship W2002072286A5051083446 @default.
- W2002072286 hasAuthorship W2002072286A5057862805 @default.
- W2002072286 hasAuthorship W2002072286A5087595506 @default.
- W2002072286 hasConcept C101544691 @default.
- W2002072286 hasConcept C104317684 @default.
- W2002072286 hasConcept C112392421 @default.
- W2002072286 hasConcept C157333092 @default.
- W2002072286 hasConcept C171958077 @default.
- W2002072286 hasConcept C190283241 @default.
- W2002072286 hasConcept C203014093 @default.
- W2002072286 hasConcept C2778277574 @default.
- W2002072286 hasConcept C2778923194 @default.
- W2002072286 hasConcept C2780130043 @default.
- W2002072286 hasConcept C31573885 @default.
- W2002072286 hasConcept C42362537 @default.
- W2002072286 hasConcept C502942594 @default.
- W2002072286 hasConcept C51785407 @default.
- W2002072286 hasConcept C54355233 @default.
- W2002072286 hasConcept C62478195 @default.
- W2002072286 hasConcept C86339819 @default.
- W2002072286 hasConcept C86803240 @default.
- W2002072286 hasConcept C8891405 @default.
- W2002072286 hasConcept C90059517 @default.
- W2002072286 hasConcept C95444343 @default.
- W2002072286 hasConceptScore W2002072286C101544691 @default.
- W2002072286 hasConceptScore W2002072286C104317684 @default.
- W2002072286 hasConceptScore W2002072286C112392421 @default.
- W2002072286 hasConceptScore W2002072286C157333092 @default.
- W2002072286 hasConceptScore W2002072286C171958077 @default.
- W2002072286 hasConceptScore W2002072286C190283241 @default.
- W2002072286 hasConceptScore W2002072286C203014093 @default.
- W2002072286 hasConceptScore W2002072286C2778277574 @default.
- W2002072286 hasConceptScore W2002072286C2778923194 @default.
- W2002072286 hasConceptScore W2002072286C2780130043 @default.
- W2002072286 hasConceptScore W2002072286C31573885 @default.
- W2002072286 hasConceptScore W2002072286C42362537 @default.
- W2002072286 hasConceptScore W2002072286C502942594 @default.
- W2002072286 hasConceptScore W2002072286C51785407 @default.
- W2002072286 hasConceptScore W2002072286C54355233 @default.
- W2002072286 hasConceptScore W2002072286C62478195 @default.
- W2002072286 hasConceptScore W2002072286C86339819 @default.
- W2002072286 hasConceptScore W2002072286C86803240 @default.
- W2002072286 hasConceptScore W2002072286C8891405 @default.
- W2002072286 hasConceptScore W2002072286C90059517 @default.
- W2002072286 hasConceptScore W2002072286C95444343 @default.
- W2002072286 hasIssue "2" @default.
- W2002072286 hasLocation W20020722861 @default.
- W2002072286 hasLocation W20020722862 @default.
- W2002072286 hasOpenAccess W2002072286 @default.
- W2002072286 hasPrimaryLocation W20020722861 @default.
- W2002072286 hasRelatedWork W1987328891 @default.
- W2002072286 hasRelatedWork W1990611714 @default.
- W2002072286 hasRelatedWork W2029312116 @default.
- W2002072286 hasRelatedWork W2083018406 @default.
- W2002072286 hasRelatedWork W2276761736 @default.
- W2002072286 hasRelatedWork W2330829715 @default.
- W2002072286 hasRelatedWork W2387527143 @default.
- W2002072286 hasRelatedWork W2523086436 @default.
- W2002072286 hasRelatedWork W3029641958 @default.
- W2002072286 hasRelatedWork W3031726892 @default.
- W2002072286 hasVolume "24" @default.
- W2002072286 isParatext "false" @default.
- W2002072286 isRetracted "false" @default.
- W2002072286 magId "2002072286" @default.
- W2002072286 workType "article" @default.