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- W2002072477 abstract "The present study was conducted to investigate the effects of cytokines on human chorionic gonadotropin (hCG) and its alpha- and beta-subunit release as well as protein synthesis in a trophoblast cell line. The human choriocarcinoma cell line, Jar, was used as a trophoblast model. Jar cells were incubated for 24 h with varying concentrations (5 × 10−4 −40 μg/ml) of the following cytokines: I1-1, I1–2, I1–3, I1–4, I1–5, I1–6, IFN-gamma, tumor necrosis factor (TNF)-alpha, M-CSF and GM-CSF. Supernatants were assayed for hCG and its alpha- and beta-subunits by immunoradiometric methods. Cytotoxic effects were assessed by trypan blue staining. Protein synthesis was measured by [3H]leucine incorporation. The cytokines I1-1 and TNF-alpha significantly stimulated hCG release. The other cytokines had no significant effect on hCG production. Protein synthesis by the Jar cells was not significantly affected by either I1-1 or TNF-alpha. However, IFN-gamma (40 μg/ml) significantly suppressed protein synthesis by the Jar cells. Trophoblast viability in the presence of TNF-alpha (10 μg/ml) and IFN-gamma (40 μg/ml) was only 40% and 50%, respectively. These results suggest that cytokines may be important regulators of trophoblast function. I1-1 appears to have a stimulatory effect on trophoblast hCG release, while TNF-alpha and IFN-gamma appear to have cytotoxic effects on trophoblast cells." @default.
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- W2002072477 date "1993-12-01" @default.
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- W2002072477 title "The effects of cytokines on human chorionic gonadotropin (hCG) production by a trophoblast cell line" @default.
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- W2002072477 doi "https://doi.org/10.1016/0165-0378(93)90066-q" @default.
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