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- W2002074089 abstract "Disturbance of the serotonergic system has been suggested as a factor in the pathogenesis of affective disorders. Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the serotonin biosynthetic pathway, and a new TPH isoform, TPH2, has been identified in the brain and localized to the long arm of chromosome 12 in a region that has been reported to contain bipolar and major depressive disorder susceptibility genes. An SNP-based association study on a case/control sample gave support to the existence of an affective disorder-associated haplotype in the TPH2 gene." @default.
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- W2002074089 date "2004-07-20" @default.
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- W2002074089 title "Support for the involvement of TPH2 gene in affective disorders" @default.
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- W2002074089 doi "https://doi.org/10.1038/sj.mp.4001557" @default.
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