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- W2002074595 abstract "The classic description of local anesthetic systemic toxicity (LAST) generally described in textbooks includes a series of progressively worsening neurologic symptoms and signs occurring shortly after the injection of local anesthetic and paralleling progressive increases in blood local anesthetic concentration, culminating in seizures and coma. In extreme cases, signs of hemodynamic instability follow and can lead to cardiovascular collapse. To characterize the clinical spectrum of LAST and compare it to the classic picture described above, we reviewed published reports of LAST during a 30-year period from 1979 to 2009. Ninety-three cases were identified and analyzed with respect to onset of toxicity and the spectrum of signs and symptoms. Sixty percent of cases followed the classic pattern of presentation. However, in the remainder of cases, symptoms were substantially delayed after the injection of local anesthetic, or involved only signs of cardiovascular compromise, with no evidence of central nervous system toxicity. Although information gained from retrospective case review cannot establish incidence, outcomes, or comparative efficacies of treatment, it can improve awareness of the clinical spectrum of LAST and, theoretically, the diagnosis and treatment of affected patients. The analytic limitations of our method make a strong case for developing a prospective, global registry of LAST as a robust alternative for educating practitioners and optimizing management of LAST." @default.
- W2002074595 created "2016-06-24" @default.
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- W2002074595 date "2010-03-01" @default.
- W2002074595 modified "2023-10-17" @default.
- W2002074595 title "Clinical Presentation of Local Anesthetic Systemic Toxicity" @default.
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- W2002074595 cites W1964392630 @default.
- W2002074595 cites W1971622360 @default.
- W2002074595 cites W1976716851 @default.
- W2002074595 cites W1976862936 @default.
- W2002074595 cites W1977756516 @default.
- W2002074595 cites W1980214447 @default.
- W2002074595 cites W1984543273 @default.
- W2002074595 cites W1986350760 @default.
- W2002074595 cites W1996777303 @default.
- W2002074595 cites W1996910799 @default.
- W2002074595 cites W1998868856 @default.
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- W2002074595 cites W2011222850 @default.
- W2002074595 cites W2011930931 @default.
- W2002074595 cites W2014999136 @default.
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- W2002074595 cites W2019265095 @default.
- W2002074595 cites W2022029920 @default.
- W2002074595 cites W2023488660 @default.
- W2002074595 cites W2025248715 @default.
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- W2002074595 cites W2045526143 @default.
- W2002074595 cites W2049977217 @default.
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- W2002074595 doi "https://doi.org/10.1097/aap.0b013e3181d2310b" @default.
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