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• W2002076163 abstract "The potential of antiepileptic drugs (AEDs) to inhibit the water transport properties of Aquaporin 4 (AQP4) was investigated using a combination of in silico and in vitro screening methods. Virtual docking studies on 14 AEDs indicated a range of docking energies that spanned approximately 40 kcal/mol, where the most stabilized energies were consistent with that of the previously identified AQP4 inhibitor acetazolamide. Nine AEDs and one bio-active metabolite were further investigated in a functional assay using AQP4 expressing Xenopus oocytes. Seven of the assayed compounds were found to inhibit AQP4 function, while three did not. A linear correlation was indicated between the in silico docking energies and the in vitro AQP4 inhibitory activity at 20 μM." @default.
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• W2002076163 date "2009-01-01" @default.
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• W2002076163 title "Inhibition of Aquaporin 4 by antiepileptic drugs" @default.
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• W2002076163 doi "https://doi.org/10.1016/j.bmc.2007.12.038" @default.
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