FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002076885> ?p ?o ?g. }

• W2002076885 endingPage "114" @default.
• W2002076885 startingPage "107" @default.
• W2002076885 abstract "Patients with cancer often develop major electrolyte disorders, which are aggravated by radiation therapy and chemotherapy and by the concomitant impairment of the renal function and the development of drug resistance. In addition, tumour cells have membranes with more negative charges than normal eukaryotic cells. This study was designed to test the hypothesis that the ability of the Ca2+ blocker verapamil to mediate the reversal of multidrug resistance (MDR) by interacting with the membrane phospholipids may be correlated with the ionic strength and membrane surface potential in resistant tumours. The permeation properties of verapamil, which is the best-known MDR-modulator, were therefore studied by quantifying its ability to induce the leakage of carboxyfluorescein through unilamellar liposomes containing various mole fractions of phosphatidic acid (xEPA=0, 0.1 and 0.3), at four different ionic strengths (I=0.052, 0.124, 0.204 and 0.318 M). The dye leakage induced by verapamil varied greatly with I, depending on xEPA. The permeation process was a co-operative one (1.3<Hill coefficient<3.5) and the permeation doses inducing 50% dye leakage (PD50) ranged between 0.2 and 1.8 mM. A highly significant multiple correlation was found to exist between the variations of log(1/PD50) with those of 1/√I and xEPA (dlog(1/PD50)/d(1/√I)=0.15±0.01, dlog(1/PD50)/dxEPA=2.07±0.08, y-intercept=2.46±0.03, P<0.000001). Kinetic studies on the permeation process showed that it involved two steps. The apparent rate constants of the slow and fast kinetic steps, which were driven by electrostatic and hydrophobic interactions, respectively, increased with the verapamil concentrations, depending on xEPA. The results provide evidence that in resistant tumours (high negative membrane surface potential), the MDR reversal by verapamil might be enhanced by favourable drug–membrane interactions in patients with severe hypo-electrolytic (Na+ and K+) disorders, whereas the MDR reversal might be reduced by unfavourable drug–membrane interactions in patients with severe hyper-electrolytic (Ca2+, Na+ and K+) disorders." @default.
• W2002076885 created "2016-06-24" @default.
• W2002076885 creator A5002165240 @default.
• W2002076885 creator A5028970804 @default.
• W2002076885 creator A5048036928 @default.
• W2002076885 date "2003-04-01" @default.
• W2002076885 modified "2023-09-27" @default.
• W2002076885 title "Interactions between verapamil and neutral and acidic liposomes: effects of the ionic strength" @default.
• W2002076885 cites W1594196316 @default.
• W2002076885 cites W1598654033 @default.
• W2002076885 cites W1964011586 @default.
• W2002076885 cites W1980102956 @default.
• W2002076885 cites W1984986786 @default.
• W2002076885 cites W1997595501 @default.
• W2002076885 cites W2018778990 @default.
• W2002076885 cites W2025581348 @default.
• W2002076885 cites W2031820970 @default.
• W2002076885 cites W2032529279 @default.
• W2002076885 cites W2038546265 @default.
• W2002076885 cites W2041910443 @default.
• W2002076885 cites W2055656322 @default.
• W2002076885 cites W2076672515 @default.
• W2002076885 cites W2082080452 @default.
• W2002076885 cites W2096873041 @default.
• W2002076885 cites W209924246 @default.
• W2002076885 cites W2108055432 @default.
• W2002076885 cites W2149534814 @default.
• W2002076885 cites W2337484355 @default.
• W2002076885 cites W2338896148 @default.
• W2002076885 cites W2512279504 @default.
• W2002076885 cites W4229652886 @default.
• W2002076885 cites W2057543829 @default.
• W2002076885 doi "https://doi.org/10.1016/s0005-2736(03)00031-2" @default.
• W2002076885 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12659951" @default.
• W2002076885 hasPublicationYear "2003" @default.
• W2002076885 type Work @default.
• W2002076885 sameAs 2002076885 @default.
• W2002076885 citedByCount "3" @default.
• W2002076885 crossrefType "journal-article" @default.
• W2002076885 hasAuthorship W2002076885A5002165240 @default.
• W2002076885 hasAuthorship W2002076885A5028970804 @default.
• W2002076885 hasAuthorship W2002076885A5048036928 @default.
• W2002076885 hasBestOaLocation W20020768851 @default.
• W2002076885 hasConcept C12554922 @default.
• W2002076885 hasConcept C178790620 @default.
• W2002076885 hasConcept C184651966 @default.
• W2002076885 hasConcept C185154212 @default.
• W2002076885 hasConcept C185592680 @default.
• W2002076885 hasConcept C187428577 @default.
• W2002076885 hasConcept C2777022698 @default.
• W2002076885 hasConcept C41625074 @default.
• W2002076885 hasConcept C43617362 @default.
• W2002076885 hasConcept C50670333 @default.
• W2002076885 hasConcept C519063684 @default.
• W2002076885 hasConcept C55493867 @default.
• W2002076885 hasConcept C71924100 @default.
• W2002076885 hasConcept C86803240 @default.
• W2002076885 hasConcept C98274493 @default.
• W2002076885 hasConceptScore W2002076885C12554922 @default.
• W2002076885 hasConceptScore W2002076885C178790620 @default.
• W2002076885 hasConceptScore W2002076885C184651966 @default.
• W2002076885 hasConceptScore W2002076885C185154212 @default.
• W2002076885 hasConceptScore W2002076885C185592680 @default.
• W2002076885 hasConceptScore W2002076885C187428577 @default.
• W2002076885 hasConceptScore W2002076885C2777022698 @default.
• W2002076885 hasConceptScore W2002076885C41625074 @default.
• W2002076885 hasConceptScore W2002076885C43617362 @default.
• W2002076885 hasConceptScore W2002076885C50670333 @default.
• W2002076885 hasConceptScore W2002076885C519063684 @default.
• W2002076885 hasConceptScore W2002076885C55493867 @default.
• W2002076885 hasConceptScore W2002076885C71924100 @default.
• W2002076885 hasConceptScore W2002076885C86803240 @default.
• W2002076885 hasConceptScore W2002076885C98274493 @default.
• W2002076885 hasIssue "1-2" @default.
• W2002076885 hasLocation W20020768851 @default.
• W2002076885 hasLocation W20020768852 @default.
• W2002076885 hasOpenAccess W2002076885 @default.
• W2002076885 hasPrimaryLocation W20020768851 @default.
• W2002076885 hasRelatedWork W1601437777 @default.
• W2002076885 hasRelatedWork W1956781751 @default.
• W2002076885 hasRelatedWork W2037236799 @default.
• W2002076885 hasRelatedWork W2067689242 @default.
• W2002076885 hasRelatedWork W2092958026 @default.
• W2002076885 hasRelatedWork W2107385066 @default.
• W2002076885 hasRelatedWork W2261320905 @default.
• W2002076885 hasRelatedWork W2801593126 @default.
• W2002076885 hasRelatedWork W2909572294 @default.
• W2002076885 hasRelatedWork W3011024476 @default.
• W2002076885 hasVolume "1611" @default.
• W2002076885 isParatext "false" @default.
• W2002076885 isRetracted "false" @default.
• W2002076885 magId "2002076885" @default.
• W2002076885 workType "article" @default.