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• W2002077419 abstract "The optimization of a series of pterin amides for use as Ricin Toxin A (RTA) inhibitors is reported. Based upon crystallographic data of a previous furan-linked pterin, various expanded furans were synthesized, linked to the pterin and tested for inhibition. Concurrently, hetero-analogs of furan were explored, leading to the discovery of more potent triazol-linked pterins. Additionally, we discuss a dramatic improvement in the synthesis of these pterin amides via a dual role by diazabicycloundecene (DBU). This synthetic enhancement facilitates rapid diversification of the previously challenging pterin heterocycle, potentially aiding future medicinal research involving this structure." @default.
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• W2002077419 date "2012-06-01" @default.
• W2002077419 modified "2023-09-30" @default.
• W2002077419 title "Optimized 5-Membered Heterocycle-Linked Pterins for the Inhibition of Ricin Toxin A" @default.
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• W2002077419 doi "https://doi.org/10.1021/ml300099t" @default.
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