FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002077468> ?p ?o ?g. }

• W2002077468 endingPage "545" @default.
• W2002077468 startingPage "536" @default.
• W2002077468 abstract "Resistance to anticancer drugs is often mediated by the overexpression of a membrane pump able to extrude many xenobiotics out of the tumour cells. The most frequently expressed of these pumps is called P‐glycoprotein and is encoded by a gene called MDR1 (for multidrug resistance). There could be great clinical interest for investigating the expression of this gene or of its product in patients' tumours, as well as in developing ways of circumventing this mechanism of resistance. Multidrug resistance can be diagnosed in tumours by molecular biology techniques (gene expression at the mRNA level), by immunological techniques (quantification of P‐glycoprotein itself) or by functional approaches (measuring dye exclusion). Numerous studies have tried to use the MDR status of tumours as a predictor of response to treatment, but they have not yet reached definitive conclusions to allow the use of this approach in routine determinations. This is because no consensus has emerged concerning the optimal technique and the best conditions for MDR determination. Continuous efforts are still required for defining appropriate standardization of the techniques. The development of MDR modulators for the treatment of resistant tumours is a promising approach requiring rigorous clinical trials with successive phase I, phase II and phase III studies. Phase I can be omitted when the reverter is already being used in therapeutics; phase II should be performed using a sequential design, in order to prove the inefficacy of the anticancer therapy before combining it to a modulator; and phase III must only be undertaken after the demonstration that responders can be recruited by the combination. However, the effect of some reverters on anticancer drug pharmacokinetics may hamper rapid evaluation. Several drugs are good candidates for MDR modulation, but definitive results are still lacking for the introduction of such combinations in standard therapeutic protocols." @default.
• W2002077468 created "2016-06-24" @default.
• W2002077468 creator A5023858440 @default.
• W2002077468 date "1999-06-01" @default.
• W2002077468 modified "2023-10-17" @default.
• W2002077468 title "Multidrug resistance in oncology: diagnostic and therapeutic approaches" @default.
• W2002077468 cites W1474183708 @default.
• W2002077468 cites W1754065147 @default.
• W2002077468 cites W1776168062 @default.
• W2002077468 cites W1858266862 @default.
• W2002077468 cites W1885665794 @default.
• W2002077468 cites W1892479582 @default.
• W2002077468 cites W1925223276 @default.
• W2002077468 cites W1950536611 @default.
• W2002077468 cites W1964444964 @default.
• W2002077468 cites W1964470226 @default.
• W2002077468 cites W1965785314 @default.
• W2002077468 cites W1967392051 @default.
• W2002077468 cites W1981034185 @default.
• W2002077468 cites W1981267478 @default.
• W2002077468 cites W1988667160 @default.
• W2002077468 cites W1997241897 @default.
• W2002077468 cites W1997879324 @default.
• W2002077468 cites W1998650250 @default.
• W2002077468 cites W1998859054 @default.
• W2002077468 cites W2000375621 @default.
• W2002077468 cites W2002973199 @default.
• W2002077468 cites W2005877531 @default.
• W2002077468 cites W2007931369 @default.
• W2002077468 cites W2009396840 @default.
• W2002077468 cites W2013276093 @default.
• W2002077468 cites W2013540958 @default.
• W2002077468 cites W2014593961 @default.
• W2002077468 cites W2016756053 @default.
• W2002077468 cites W2017654394 @default.
• W2002077468 cites W2018652769 @default.
• W2002077468 cites W2023520902 @default.
• W2002077468 cites W2024463580 @default.
• W2002077468 cites W2028533496 @default.
• W2002077468 cites W2029185839 @default.
• W2002077468 cites W2033539216 @default.
• W2002077468 cites W2035142996 @default.
• W2002077468 cites W2040342801 @default.
• W2002077468 cites W2043143197 @default.
• W2002077468 cites W2044517385 @default.
• W2002077468 cites W2052797596 @default.
• W2002077468 cites W2068561160 @default.
• W2002077468 cites W2069943574 @default.
• W2002077468 cites W2072834181 @default.
• W2002077468 cites W2078822262 @default.
• W2002077468 cites W2078877172 @default.
• W2002077468 cites W2079961141 @default.
• W2002077468 cites W2083913321 @default.
• W2002077468 cites W2088419541 @default.
• W2002077468 cites W2090421237 @default.
• W2002077468 cites W2094964562 @default.
• W2002077468 cites W2097878215 @default.
• W2002077468 cites W2099687525 @default.
• W2002077468 cites W2102458361 @default.
• W2002077468 cites W2118234018 @default.
• W2002077468 cites W2121167726 @default.
• W2002077468 cites W2133408654 @default.
• W2002077468 cites W2137267834 @default.
• W2002077468 cites W2153413276 @default.
• W2002077468 cites W2161663775 @default.
• W2002077468 cites W2167564928 @default.
• W2002077468 cites W2198835790 @default.
• W2002077468 cites W2223026985 @default.
• W2002077468 cites W2253853328 @default.
• W2002077468 cites W2279016967 @default.
• W2002077468 cites W2290583892 @default.
• W2002077468 cites W2301279425 @default.
• W2002077468 cites W2315260956 @default.
• W2002077468 cites W2411255792 @default.
• W2002077468 cites W2416083307 @default.
• W2002077468 cites W2416522533 @default.
• W2002077468 doi "https://doi.org/10.1046/j.1365-2362.1999.00495.x" @default.
• W2002077468 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10354216" @default.
• W2002077468 hasPublicationYear "1999" @default.
• W2002077468 type Work @default.
• W2002077468 sameAs 2002077468 @default.
• W2002077468 citedByCount "70" @default.
• W2002077468 countsByYear W20020774682012 @default.
• W2002077468 countsByYear W20020774682013 @default.
• W2002077468 countsByYear W20020774682015 @default.
• W2002077468 countsByYear W20020774682022 @default.
• W2002077468 crossrefType "journal-article" @default.
• W2002077468 hasAuthorship W2002077468A5023858440 @default.
• W2002077468 hasBestOaLocation W20020774681 @default.
• W2002077468 hasConcept C111472728 @default.
• W2002077468 hasConcept C114851261 @default.
• W2002077468 hasConcept C133936738 @default.
• W2002077468 hasConcept C138885662 @default.
• W2002077468 hasConcept C143998085 @default.
• W2002077468 hasConcept C2778707650 @default.
• W2002077468 hasConcept C502942594 @default.
• W2002077468 hasConcept C535046627 @default.
• W2002077468 hasConcept C54355233 @default.

• next