FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002078725> ?p ?o ?g. }

• W2002078725 endingPage "e100326" @default.
• W2002078725 startingPage "e100326" @default.
• W2002078725 abstract "Purpose To investigate the association between genetic polymorphisms of growth factor-related genes and prognosis in patients with advanced esophageal squamous cell carcinoma (ESCC). Patients and Methods A total of 334 ESCC patients with advanced tumor stages (stages IIB, III and IV) were enrolled in the study. The genotypes of 14 candidate single nucleotide polymorphisms (SNPs) involved in growth factor-related functions were analyzed using iPLEX Gold technology from the genomic DNA of peripheral leukocytes, and were correlated with the clinical outcome of patients. Serum levels of growth factors were examined by enzyme-linked immunosorbent assay (ELISA). Results The genetic polymorphisms of EGF:rs4444903, EGF:rs2237051 and VEGF:rs2010963 showed significant associations with overall survival (OS) of advanced ESCC patients (A/A+ A/G vs. GG, [HR = 0.77, 95% CI = 0.60–0.99, P = 0.039 for rs4444903; A/G+ G/G vs. A/A, [HR = 0.74, 95% CI = 0.58–0.95, P = 0.019 for rs2237051; G/G+G/C vs. C/C, [HR] inves = 0.69, 95% CI = 0.50–0.95, P = 0.023 for rs2010963). EGFR:rs2227983 and 3 SNPs of PIK3CA also showed borderline significant correlation with OS of advanced ESCC patients (P = 0.058 for rs2227983; P = 0.069, 0.091 and 0.067 for rs6443624, rs7651265 and rs7621329 of PIK3CA respectively). According to cumulative effect analysis of multiple SNPs, patients carrying 4 unfavorable genotypes exhibited more than a 3-fold increased risk of mortality. Finally, both EGF and VEGF expression levels significantly associated with patient mortality. Conclusion The genetic variants and expression levels of EGF and VEGF can serve as prognostic predictors in patients with advanced ESCC, and thus provide more information for optimizing personalized therapies for patients with ESCC." @default.
• W2002078725 created "2016-06-24" @default.
• W2002078725 creator A5034097034 @default.
• W2002078725 creator A5037016612 @default.
• W2002078725 creator A5040542459 @default.
• W2002078725 creator A5050614690 @default.
• W2002078725 creator A5061073072 @default.
• W2002078725 creator A5080087416 @default.
• W2002078725 date "2014-06-19" @default.
• W2002078725 modified "2023-10-14" @default.
• W2002078725 title "Genetic Variants of EGF and VEGF Predict Prognosis of Patients with Advanced Esophageal Squamous Cell Carcinoma" @default.
• W2002078725 cites W1577889898 @default.
• W2002078725 cites W1971211622 @default.
• W2002078725 cites W1976198146 @default.
• W2002078725 cites W1983534375 @default.
• W2002078725 cites W1986400700 @default.
• W2002078725 cites W1990683299 @default.
• W2002078725 cites W1993797874 @default.
• W2002078725 cites W1995613871 @default.
• W2002078725 cites W1999647740 @default.
• W2002078725 cites W2008940139 @default.
• W2002078725 cites W2013355610 @default.
• W2002078725 cites W2014938285 @default.
• W2002078725 cites W2015961921 @default.
• W2002078725 cites W2020653550 @default.
• W2002078725 cites W2023575200 @default.
• W2002078725 cites W2040795070 @default.
• W2002078725 cites W2045971322 @default.
• W2002078725 cites W2051120695 @default.
• W2002078725 cites W2053272214 @default.
• W2002078725 cites W2055448650 @default.
• W2002078725 cites W2060712022 @default.
• W2002078725 cites W2071375722 @default.
• W2002078725 cites W2085954897 @default.
• W2002078725 cites W2087031979 @default.
• W2002078725 cites W2088636164 @default.
• W2002078725 cites W2088980138 @default.
• W2002078725 cites W2093678620 @default.
• W2002078725 cites W2120243407 @default.
• W2002078725 cites W2120638451 @default.
• W2002078725 cites W2122166737 @default.
• W2002078725 cites W2122473859 @default.
• W2002078725 cites W2146447599 @default.
• W2002078725 cites W2147017705 @default.
• W2002078725 cites W2152922289 @default.
• W2002078725 cites W2153164684 @default.
• W2002078725 cites W2155838479 @default.
• W2002078725 cites W2158734599 @default.
• W2002078725 cites W2163713521 @default.
• W2002078725 cites W2167241562 @default.
• W2002078725 cites W2170428165 @default.
• W2002078725 cites W2337262864 @default.
• W2002078725 cites W2338880854 @default.
• W2002078725 cites W4235333461 @default.
• W2002078725 cites W4252560545 @default.
• W2002078725 doi "https://doi.org/10.1371/journal.pone.0100326" @default.
• W2002078725 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4063891" @default.
• W2002078725 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24945674" @default.
• W2002078725 hasPublicationYear "2014" @default.
• W2002078725 type Work @default.
• W2002078725 sameAs 2002078725 @default.
• W2002078725 citedByCount "30" @default.
• W2002078725 countsByYear W20020787252014 @default.
• W2002078725 countsByYear W20020787252015 @default.
• W2002078725 countsByYear W20020787252016 @default.
• W2002078725 countsByYear W20020787252017 @default.
• W2002078725 countsByYear W20020787252019 @default.
• W2002078725 countsByYear W20020787252020 @default.
• W2002078725 countsByYear W20020787252021 @default.
• W2002078725 countsByYear W20020787252022 @default.
• W2002078725 countsByYear W20020787252023 @default.
• W2002078725 crossrefType "journal-article" @default.
• W2002078725 hasAuthorship W2002078725A5034097034 @default.
• W2002078725 hasAuthorship W2002078725A5037016612 @default.
• W2002078725 hasAuthorship W2002078725A5040542459 @default.
• W2002078725 hasAuthorship W2002078725A5050614690 @default.
• W2002078725 hasAuthorship W2002078725A5061073072 @default.
• W2002078725 hasAuthorship W2002078725A5080087416 @default.
• W2002078725 hasBestOaLocation W20020787251 @default.
• W2002078725 hasConcept C104317684 @default.
• W2002078725 hasConcept C121608353 @default.
• W2002078725 hasConcept C126322002 @default.
• W2002078725 hasConcept C135763542 @default.
• W2002078725 hasConcept C143998085 @default.
• W2002078725 hasConcept C153209595 @default.
• W2002078725 hasConcept C170493617 @default.
• W2002078725 hasConcept C2776362946 @default.
• W2002078725 hasConcept C2777546739 @default.
• W2002078725 hasConcept C2779742542 @default.
• W2002078725 hasConcept C2994415158 @default.
• W2002078725 hasConcept C54355233 @default.
• W2002078725 hasConcept C71924100 @default.
• W2002078725 hasConcept C86803240 @default.
• W2002078725 hasConcept C90924648 @default.
• W2002078725 hasConceptScore W2002078725C104317684 @default.
• W2002078725 hasConceptScore W2002078725C121608353 @default.
• W2002078725 hasConceptScore W2002078725C126322002 @default.
• W2002078725 hasConceptScore W2002078725C135763542 @default.

• next