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- W2002080321 abstract "Many cultured human cell lines show large synergistic cytotoxicity when an inhibitor of dihydrofolate reductase (EC 1.5.1.3) is combined with an antifolate inhibitor of thymidylate synthase (EC 2. 1.1.45) or with an antifolate inhibitor of glycinamide ribonucleotide formyltransferase (EC 2.1.2.2). These synergistic interactions are dependent on medium folic acid concentration and are greatly enhanced by increasing folic acid levels. Synergism is seen only when the thymidylate synthase or glycinamide ribonucleotide formyltransferase inhibitor is polyglutamylatable. Here we will briefly outline the rigorous method used to quantitate synergistic interactions by measuring alpha, a response surface-based parameter; give examples of synergistic interactions from the current literature; and evaluate proposals offered to explain the metabolic basis of the synergism." @default.
- W2002080321 created "2016-06-24" @default.
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- W2002080321 date "2000-03-01" @default.
- W2002080321 modified "2023-09-23" @default.
- W2002080321 title "Synergistic interactions among antifolates" @default.
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- W2002080321 doi "https://doi.org/10.1016/s0163-7258(99)00056-x" @default.
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