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• W2002081009 abstract "The two fundamental lineages of photoreceptor cells, microvillar and ciliary, were long thought to be a prerogative of invertebrate and vertebrate organisms, respectively. However evidence of their ancient origin, preceding the divergence of these two branches of metazoa, suggests instead that they should be ubiquitously distributed. Melanopsin-expressing ‘circadian’ light receptors may represent the remnants of the microvillar photoreceptors amongst vertebrates, but they lack the characteristic architecture of this lineage, and much remains to be clarified about their signaling mechanisms. Hesse and Joseph cells of the neural tube of amphioxus (Branchiostoma fl.) – the most basal chordate extant - turn out to be depolarizing primary microvillar photoreceptors, that generate a melanopsin-initiated, PLC-dependent response to light, mobilizing internal Ca and increasing a membrane conductance selective to Na and Ca ions. As such, they represent a canonical instance of invertebrate-like visual cells in the chordate phylum." @default.
• W2002081009 created "2016-06-24" @default.
• W2002081009 creator A5057202299 @default.
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• W2002081009 date "2009-09-01" @default.
• W2002081009 modified "2023-10-14" @default.
• W2002081009 title "Melanopsin-mediated light-sensing in amphioxus" @default.
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• W2002081009 doi "https://doi.org/10.4161/cib.2.5.9244" @default.
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