Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002085275> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2002085275 endingPage "81" @default.
- W2002085275 startingPage "74" @default.
- W2002085275 abstract "Phosphorylation of the herpes simplex virus (HSV) VP22 protein is regulated by cellular kinases and the UL13 viral kinase, but the sites at which these enzymes induce phosphorylation of HSV-2 VP22 are not known. Using serine-to-alanine mutants to map phosphorylation sites on HSV-2 VP22 in cells, we made three major observations. First, phosphorylation by a cellular kinase mapped to serines 70, 71, and/or 72 within CKII consensus sites analogous to previously identified phosphorylation sites in HSV-1 VP22. Second, we mapped UL13-mediated phosphorylation of HSV-2 VP22 to serines 28 and 34, describing for the first time UL13-dependent phosphorylation sites on VP22. Third, previously identified VP22-associated cellular kinase sites in HSV-1 VP22 (serines 292 and 294) were not phosphorylated in HSV-2 VP22 (serines 291 and 293). VP22 expressed alone accumulated in the cytoplasm and to a lesser extent in the nucleus. Phosphorylation by endogenous cellular kinase(s) did not alter the localization of VP22. Co-expression of HSV-2 VP22 with active UL13, but not with enzymatically inactive UL13, resulted in nuclear accumulation of VP22 and altered nuclear morphology. Surprisingly, redistribution of VP22 to the nucleus occurred independently of UL13-induced phosphorylation of VP22. The altered nuclear morphology of UL13-expressing cells was not due to apoptosis. These results demonstrate that phosphorylation of HSV-2 VP22 at multiple serine residues is induced by UL13 and cellular kinase(s), and that the nuclear/cytoplasmic distribution of VP22 is independent of its phosphorylation status but is controlled indirectly by UL13 kinase activity." @default.
- W2002085275 created "2016-06-24" @default.
- W2002085275 creator A5007278342 @default.
- W2002085275 creator A5014880617 @default.
- W2002085275 creator A5049376781 @default.
- W2002085275 creator A5061179606 @default.
- W2002085275 date "2004-12-01" @default.
- W2002085275 modified "2023-09-26" @default.
- W2002085275 title "Herpes simplex virus 2 VP22 phosphorylation induced by cellular and viral kinases does not influence intracellular localization" @default.
- W2002085275 cites W1494730114 @default.
- W2002085275 cites W1525451066 @default.
- W2002085275 cites W1548611677 @default.
- W2002085275 cites W1720083525 @default.
- W2002085275 cites W1964008079 @default.
- W2002085275 cites W1984643643 @default.
- W2002085275 cites W2015698598 @default.
- W2002085275 cites W2018537155 @default.
- W2002085275 cites W2019395700 @default.
- W2002085275 cites W2042176203 @default.
- W2002085275 cites W2050925571 @default.
- W2002085275 cites W2062924063 @default.
- W2002085275 cites W2074336496 @default.
- W2002085275 cites W2076995326 @default.
- W2002085275 cites W2082052130 @default.
- W2002085275 cites W2089414651 @default.
- W2002085275 cites W2103125422 @default.
- W2002085275 cites W2121086174 @default.
- W2002085275 cites W2130589612 @default.
- W2002085275 cites W2144378803 @default.
- W2002085275 cites W2153863481 @default.
- W2002085275 doi "https://doi.org/10.1016/j.virol.2004.08.034" @default.
- W2002085275 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15527835" @default.
- W2002085275 hasPublicationYear "2004" @default.
- W2002085275 type Work @default.
- W2002085275 sameAs 2002085275 @default.
- W2002085275 citedByCount "17" @default.
- W2002085275 countsByYear W20020852752012 @default.
- W2002085275 countsByYear W20020852752013 @default.
- W2002085275 countsByYear W20020852752014 @default.
- W2002085275 countsByYear W20020852752015 @default.
- W2002085275 countsByYear W20020852752020 @default.
- W2002085275 countsByYear W20020852752022 @default.
- W2002085275 crossrefType "journal-article" @default.
- W2002085275 hasAuthorship W2002085275A5007278342 @default.
- W2002085275 hasAuthorship W2002085275A5014880617 @default.
- W2002085275 hasAuthorship W2002085275A5049376781 @default.
- W2002085275 hasAuthorship W2002085275A5061179606 @default.
- W2002085275 hasBestOaLocation W20020852751 @default.
- W2002085275 hasConcept C11960822 @default.
- W2002085275 hasConcept C153911025 @default.
- W2002085275 hasConcept C159047783 @default.
- W2002085275 hasConcept C184235292 @default.
- W2002085275 hasConcept C190062978 @default.
- W2002085275 hasConcept C2522874641 @default.
- W2002085275 hasConcept C2776414213 @default.
- W2002085275 hasConcept C2781196997 @default.
- W2002085275 hasConcept C2910050888 @default.
- W2002085275 hasConcept C86803240 @default.
- W2002085275 hasConcept C95444343 @default.
- W2002085275 hasConcept C97029542 @default.
- W2002085275 hasConceptScore W2002085275C11960822 @default.
- W2002085275 hasConceptScore W2002085275C153911025 @default.
- W2002085275 hasConceptScore W2002085275C159047783 @default.
- W2002085275 hasConceptScore W2002085275C184235292 @default.
- W2002085275 hasConceptScore W2002085275C190062978 @default.
- W2002085275 hasConceptScore W2002085275C2522874641 @default.
- W2002085275 hasConceptScore W2002085275C2776414213 @default.
- W2002085275 hasConceptScore W2002085275C2781196997 @default.
- W2002085275 hasConceptScore W2002085275C2910050888 @default.
- W2002085275 hasConceptScore W2002085275C86803240 @default.
- W2002085275 hasConceptScore W2002085275C95444343 @default.
- W2002085275 hasConceptScore W2002085275C97029542 @default.
- W2002085275 hasIssue "1" @default.
- W2002085275 hasLocation W20020852751 @default.
- W2002085275 hasLocation W20020852752 @default.
- W2002085275 hasOpenAccess W2002085275 @default.
- W2002085275 hasPrimaryLocation W20020852751 @default.
- W2002085275 hasRelatedWork W1520436089 @default.
- W2002085275 hasRelatedWork W1589508537 @default.
- W2002085275 hasRelatedWork W1640595204 @default.
- W2002085275 hasRelatedWork W1964515703 @default.
- W2002085275 hasRelatedWork W2078359362 @default.
- W2002085275 hasRelatedWork W2152730118 @default.
- W2002085275 hasRelatedWork W2316548913 @default.
- W2002085275 hasRelatedWork W2340742655 @default.
- W2002085275 hasRelatedWork W2883746216 @default.
- W2002085275 hasRelatedWork W595461251 @default.
- W2002085275 hasVolume "330" @default.
- W2002085275 isParatext "false" @default.
- W2002085275 isRetracted "false" @default.
- W2002085275 magId "2002085275" @default.
- W2002085275 workType "article" @default.