FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002085757> ?p ?o ?g. }

• W2002085757 endingPage "1250" @default.
• W2002085757 startingPage "1242" @default.
• W2002085757 abstract "Diabetic patients are frequently afflicted with medial artery calcification, a predictor of cardiovascular mortality. Diabetes induced the expression of osteopontin in arterial vasculature, which is an indicator of disease progression in artery calcification and vascular stiffness. Signal transduction and strategies that suppress high glucose-induced osteopontin expression in arterial vascular smooth muscle cells is investigated.The incubation of rat aortic smooth muscle cells under high glucose concentration increased osteopontin protein secretion and mRNA expression. Treatment with dipyridamole decreased high glucose-induced osteopontin expression and secretion. Dipyridamole decreased glucose-induced osteopontin through inhibition of phosphodiesterase, thereby increasing intracellular levels of adenosine-3',5'-cyclic monophosphate (cAMP) and guanosine-3',5'-cyclic monophosphate (cGMP), and increased thioredoxin expression to inhibit the reactive oxygen species (ROS) system. Induction of osteopontin was reversed when cells were pretreated with N-[2-bromocinnamyl(amino)ethyl]-5-isoquinolinesulfonamide (H89, cAMP-dependent protein kinase inhibitor), KT5823 (cGMP-dependent protein kinase inhibitor), or dinitrochlorobenzene (thioredoxin reductase inhibitor). The antioxidant, N-acetyl-L-cysteine, suppressed glucose-induced osteopontin expression by decreasing ROS concentration. Both H89 and KT5823 downregulated thioredoxin expression.These results suggest a novel effect for dipyridamole to suppress high glucose-induced osteopontin protein secretion and mRNA expression. Dipyridamole has antioxidant properties and a phosphodiesterase inhibitor activity, which might be useful to ameliorate diabetic vasculopathy and its cardiovascular complications." @default.
• W2002085757 created "2016-06-24" @default.
• W2002085757 creator A5003338311 @default.
• W2002085757 creator A5011999102 @default.
• W2002085757 creator A5020322982 @default.
• W2002085757 creator A5040499312 @default.
• W2002085757 creator A5083289858 @default.
• W2002085757 creator A5086415420 @default.
• W2002085757 date "2010-01-01" @default.
• W2002085757 modified "2023-10-18" @default.
• W2002085757 title "Dipyridamole Suppresses High Glucose-Induced Osteopontin Secretion and mRNA Expression in Rat Aortic Smooth Muscle Cells" @default.
• W2002085757 cites W1491017717 @default.
• W2002085757 cites W1942455675 @default.
• W2002085757 cites W1963980963 @default.
• W2002085757 cites W1965356552 @default.
• W2002085757 cites W1966120281 @default.
• W2002085757 cites W1971838090 @default.
• W2002085757 cites W1975597097 @default.
• W2002085757 cites W1978508442 @default.
• W2002085757 cites W1992234212 @default.
• W2002085757 cites W2006877529 @default.
• W2002085757 cites W2008675789 @default.
• W2002085757 cites W2015626100 @default.
• W2002085757 cites W2016963136 @default.
• W2002085757 cites W2017495637 @default.
• W2002085757 cites W2067013800 @default.
• W2002085757 cites W2068698868 @default.
• W2002085757 cites W2075782719 @default.
• W2002085757 cites W2080660353 @default.
• W2002085757 cites W2091874442 @default.
• W2002085757 cites W2096163451 @default.
• W2002085757 cites W2112692194 @default.
• W2002085757 cites W2116381107 @default.
• W2002085757 cites W2121511741 @default.
• W2002085757 cites W2132956374 @default.
• W2002085757 cites W2135053865 @default.
• W2002085757 cites W2160055240 @default.
• W2002085757 cites W2166389885 @default.
• W2002085757 cites W2402156397 @default.
• W2002085757 cites W2084395780 @default.
• W2002085757 doi "https://doi.org/10.1253/circj.cj-09-0561" @default.
• W2002085757 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20453393" @default.
• W2002085757 hasPublicationYear "2010" @default.
• W2002085757 type Work @default.
• W2002085757 sameAs 2002085757 @default.
• W2002085757 citedByCount "17" @default.
• W2002085757 countsByYear W20020857572013 @default.
• W2002085757 countsByYear W20020857572014 @default.
• W2002085757 countsByYear W20020857572016 @default.
• W2002085757 countsByYear W20020857572017 @default.
• W2002085757 countsByYear W20020857572018 @default.
• W2002085757 crossrefType "journal-article" @default.
• W2002085757 hasAuthorship W2002085757A5003338311 @default.
• W2002085757 hasAuthorship W2002085757A5011999102 @default.
• W2002085757 hasAuthorship W2002085757A5020322982 @default.
• W2002085757 hasAuthorship W2002085757A5040499312 @default.
• W2002085757 hasAuthorship W2002085757A5083289858 @default.
• W2002085757 hasAuthorship W2002085757A5086415420 @default.
• W2002085757 hasBestOaLocation W20020857571 @default.
• W2002085757 hasConcept C126322002 @default.
• W2002085757 hasConcept C134018914 @default.
• W2002085757 hasConcept C184235292 @default.
• W2002085757 hasConcept C185592680 @default.
• W2002085757 hasConcept C2776766087 @default.
• W2002085757 hasConcept C2779395532 @default.
• W2002085757 hasConcept C2780804394 @default.
• W2002085757 hasConcept C2780994212 @default.
• W2002085757 hasConcept C2992686903 @default.
• W2002085757 hasConcept C519581460 @default.
• W2002085757 hasConcept C55493867 @default.
• W2002085757 hasConcept C71924100 @default.
• W2002085757 hasConcept C86803240 @default.
• W2002085757 hasConcept C97029542 @default.
• W2002085757 hasConceptScore W2002085757C126322002 @default.
• W2002085757 hasConceptScore W2002085757C134018914 @default.
• W2002085757 hasConceptScore W2002085757C184235292 @default.
• W2002085757 hasConceptScore W2002085757C185592680 @default.
• W2002085757 hasConceptScore W2002085757C2776766087 @default.
• W2002085757 hasConceptScore W2002085757C2779395532 @default.
• W2002085757 hasConceptScore W2002085757C2780804394 @default.
• W2002085757 hasConceptScore W2002085757C2780994212 @default.
• W2002085757 hasConceptScore W2002085757C2992686903 @default.
• W2002085757 hasConceptScore W2002085757C519581460 @default.
• W2002085757 hasConceptScore W2002085757C55493867 @default.
• W2002085757 hasConceptScore W2002085757C71924100 @default.
• W2002085757 hasConceptScore W2002085757C86803240 @default.
• W2002085757 hasConceptScore W2002085757C97029542 @default.
• W2002085757 hasIssue "6" @default.
• W2002085757 hasLocation W20020857571 @default.
• W2002085757 hasLocation W20020857572 @default.
• W2002085757 hasOpenAccess W2002085757 @default.
• W2002085757 hasPrimaryLocation W20020857571 @default.
• W2002085757 hasRelatedWork W1965794701 @default.
• W2002085757 hasRelatedWork W1997650562 @default.
• W2002085757 hasRelatedWork W2002085757 @default.
• W2002085757 hasRelatedWork W2064901336 @default.
• W2002085757 hasRelatedWork W2122859970 @default.
• W2002085757 hasRelatedWork W2143238233 @default.

• next