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• W2002086557 abstract "Abstract A sustained delivery system for interleukin‐1 receptor antagonist (IL‐1Ra) may have great therapeutic and industrial potential due to the cytokine activity as an IL‐1 inhibitor. Here, we investigated the capability of biodegradable polymeric microspheres to sustain the release and prolong the therapeutic efficacy of IL‐1Ra. IL‐1Ra was encapsulated within rapidly degrading poly(lactic/glycolic acid) PLGA RG502H microspheres, which showed a desirable release profile of IL‐1Ra in vitro. Pharmacokinetic study in mice revealed elevated serum levels of the recombinant IL‐1Ra (rIL‐1Ra) for up to 8 days following subcutaneous injection of IL‐1Ra microspheres. In comparison, the serum levels of rIL‐1Ra following subcutaneous or intravenous bolus injection of the soluble cytokine decreased very rapidly; within 48 h no recombinant cytokine was detected in mice sera. The sustained delivery of rIL‐1Ra for over two weeks was efficient in inhibiting IL‐1ß‐stimulated induction of serum IL‐6. These results suggest that the present therapeutic protocol of daily bolus injections of the IL‐1Ra may be replaced by a weekly injection of IL‐1Ra within PLGA RG502H microspheres." @default.
• W2002086557 created "2016-06-24" @default.
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• W2002086557 date "2005-09-01" @default.
• W2002086557 modified "2023-10-16" @default.
• W2002086557 title "Sustained release of IL-1Ra from biodegradable microspheres prolongs its IL-1-neutralizing effects" @default.
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• W2002086557 doi "https://doi.org/10.1560/dybg-twdv-j8pf-7w9t" @default.
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