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- W2002086746 abstract "New carbohydrate-conjugated heterobimetallic complexes [C(32)H(62)N(10)O(8)NiSn(2)Cl(4)]Cl(2)(1) and [C(32)H(62)N(10)O(8)CuSn(2)Cl(4)]Cl(2) (2) were synthesized and characterized by spectroscopic (IR, (1)H, (13)C, and (119)Sn NMR, EPR, UV-vis, ESI-MS) and analytical methods. The interaction studies of 2 with CT DNA were studied by using various biophysical techniques, which showed high binding affinity of 2 toward CT DNA. The extent of interaction was further confirmed by the interaction of 2 with the nucleotides viz.; 5'-AMP, 5'-CMP, 5'-GMP, and 5'-TMP, by absorption titration. (1)H, (31)P, (119)Sn NMR spectroscopy further validated the interaction mode of 2 with 5'-GMP. The electrophoresis pattern observed for 2 with supercoiled pBR322 DNA, exhibited significantly good nuclease activity following oxidative pathway. The preferential selectivity of 2 toward the major groove was observed on interaction of 2 with pBR322 DNA, in the presence of standard groove binders viz.; DAPI and methyl green. Additionally, in vitro antitumor activity of 2 was evaluated on a panel of human cancer cell lines, exhibiting remarkable cytotoxicity activity against Colo205 (colon) and MCF7 (breast) cell lines with GI(50) values <10 μg/mL." @default.
- W2002086746 created "2016-06-24" @default.
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- W2002086746 date "2011-12-01" @default.
- W2002086746 modified "2023-09-23" @default.
- W2002086746 title "Carbohydrate-conjugate heterobimetallic complexes: synthesis, DNA binding studies, artificial nuclease activity and in vitro cytotoxicity" @default.
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- W2002086746 cites W1977254582 @default.
- W2002086746 cites W1977767796 @default.
- W2002086746 cites W1979339679 @default.
- W2002086746 cites W1982396826 @default.
- W2002086746 cites W1983486256 @default.
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- W2002086746 cites W1998004406 @default.
- W2002086746 cites W2002158887 @default.
- W2002086746 cites W2009627348 @default.
- W2002086746 cites W2011233623 @default.
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- W2002086746 doi "https://doi.org/10.1016/j.carres.2011.10.010" @default.
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